Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3410788..3411431 Replicon chromosome
Accession NZ_CP023407
Organism Streptomyces fungicidicus strain TXX3120

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag CNQ36_RS15315 Protein ID WP_121546428.1
Coordinates 3410788..3411129 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag CNQ36_RS15320 Protein ID WP_121546429.1
Coordinates 3411126..3411431 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ36_RS15300 3406716..3408314 - 1599 WP_121546425.1 acyl-CoA carboxylase subunit beta -
CNQ36_RS15305 3408311..3409987 - 1677 WP_121546426.1 DUF1446 domain-containing protein -
CNQ36_RS15310 3409984..3410778 - 795 WP_121546427.1 TIGR03084 family protein -
CNQ36_RS15315 3410788..3411129 + 342 WP_121546428.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNQ36_RS15320 3411126..3411431 + 306 WP_121546429.1 helix-turn-helix transcriptional regulator Antitoxin
CNQ36_RS15325 3411506..3412486 - 981 WP_121546430.1 EamA family transporter -
CNQ36_RS15330 3412745..3413197 + 453 WP_121546431.1 NUDIX domain-containing protein -
CNQ36_RS15335 3413229..3416090 - 2862 WP_121546432.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13063.15 Da        Isoelectric Point: 11.4533

>T81205 WP_121546428.1 NZ_CP023407:3410788-3411129 [Streptomyces fungicidicus]
MAAPPKTIKHACWLLPRPQREVGPALRRPTVGAIERSRFRNMRELRPRNGGTVSIRMLFVFDPERRAIFLVAGNKATGRR
WASWYPRAIKEADDKYTAYLEALEQEKKEGQGR

Download         Length: 342 bp

>T81205 NZ_CP023407:3410788-3411129 [Streptomyces fungicidicus]
ATGGCAGCACCCCCCAAAACAATCAAGCACGCTTGCTGGCTCTTACCGCGACCCCAACGTGAAGTGGGTCCGGCGCTTCG
GCGGCCGACGGTCGGCGCCATCGAGAGGAGCCGCTTCCGGAACATGCGGGAGTTACGCCCACGCAACGGCGGGACGGTGA
GCATCCGGATGCTGTTCGTCTTCGACCCCGAGCGTCGGGCCATCTTCCTGGTGGCGGGCAACAAGGCGACCGGACGCCGC
TGGGCGTCCTGGTACCCGCGAGCGATCAAAGAGGCAGACGACAAGTACACGGCATACCTTGAGGCGCTGGAGCAGGAAAA
GAAGGAAGGGCAGGGCAGATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10854.41 Da        Isoelectric Point: 6.4671

>AT81205 WP_121546429.1 NZ_CP023407:3411126-3411431 [Streptomyces fungicidicus]
MNLGSMDDLTADITPEKRERIDAIKAEMIDAERGHELAALRKAQGFTQVQVAKAMGVTQGRVSQIERGTARLDTSTMAAY
LHAIGGELTITATVGNLSVRL

Download         Length: 306 bp

>AT81205 NZ_CP023407:3411126-3411431 [Streptomyces fungicidicus]
ATGAATCTCGGCTCCATGGACGATCTGACGGCCGACATCACCCCCGAGAAGCGCGAACGCATCGACGCCATCAAGGCGGA
GATGATCGACGCGGAACGGGGACACGAGCTGGCCGCCCTCCGCAAGGCCCAGGGTTTCACGCAGGTCCAGGTCGCCAAGG
CGATGGGCGTCACTCAGGGCCGGGTCAGTCAGATCGAGCGGGGTACCGCCCGTCTCGACACCTCAACGATGGCGGCCTAC
CTGCACGCAATCGGCGGCGAGCTGACCATAACGGCCACTGTCGGGAACCTTTCGGTACGGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References