Detailed information of TA system TA081178

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2269645..2269862
• Replicon: chromosome
• Accession: NZ_CP023390
• Organism: Staphylococcus aureus subsp. aureus str. Newman strain NYU_Newman

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: CNH35_RS12115
• Protein ID: WP_001802298.1
• Coordinates: 2269758..2269862 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2269645..2269700 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNH35_RS12095	2265848..2266513	-	666	WP_001024094.1	SDR family oxidoreductase	-
CNH35_RS12100	2266665..2266985	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
CNH35_RS12105	2266987..2267967	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
CNH35_RS12110	2268233..2269324	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2269645..2269700	+	56	-	-	Antitoxin
CNH35_RS12115	2269758..2269862	-	105	WP_001802298.1	hypothetical protein	Toxin
CNH35_RS15315	2270023..2270506	-	484	Protein_2247	recombinase family protein	-
CNH35_RS12125	2270549..2271685	-	1137	WP_000115564.1	SAP domain-containing protein	-
CNH35_RS12130	2271974..2272066	+	93	WP_001790138.1	hypothetical protein	-
CNH35_RS12135	2272771..2273628	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
CNH35_RS12140	2273696..2274478	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T81178 WP_001802298.1 NZ_CP023390:c2269862-2269758 [Staphylococcus aureus subsp. aureus str. Newman]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T81178 NZ_CP023390:c2269862-2269758 [Staphylococcus aureus subsp. aureus str. Newman]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT81178 NZ_CP023390:2269645-2269700 [Staphylococcus aureus subsp. aureus str. Newman]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin