Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 320520..320777 Replicon chromosome
Accession NZ_CP023388
Organism Escherichia coli strain 1105

Toxin (Protein)


Gene name hokA Uniprot ID F4VKL0
Locus tag CNQ47_RS01675 Protein ID WP_001135735.1
Coordinates 320625..320777 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 320520..320574 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ47_RS01655 315745..316740 - 996 WP_001182653.1 O-acetyltransferase WecH -
CNQ47_RS01660 316915..317214 + 300 WP_000980111.1 YsaB family lipoprotein -
CNQ47_RS01665 317309..318220 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
CNQ47_RS01670 318230..320299 + 2070 WP_001291774.1 glycine--tRNA ligase subunit beta -
- 320520..320574 - 55 - - Antitoxin
CNQ47_RS01675 320625..320777 + 153 WP_001135735.1 type I toxin-antitoxin system toxin HokA Toxin
CNQ47_RS26920 320766..320825 - 60 WP_212591412.1 hypothetical protein -
CNQ47_RS01680 320965..321177 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CNQ47_RS01685 321458..321748 - 291 WP_000455798.1 HTH-type transcriptional regulator -
CNQ47_RS01690 322182..322892 + 711 WP_000190517.1 DUF3053 domain-containing protein -
CNQ47_RS01695 322942..323916 - 975 WP_000805027.1 glyoxylate/hydroxypyruvate reductase GhrB -
CNQ47_RS01700 324020..324679 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5928.20 Da        Isoelectric Point: 7.6368

>T81130 WP_001135735.1 NZ_CP023388:320625-320777 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGCYELAAFLACNLKE

Download         Length: 153 bp

>T81130 NZ_CP023388:320625-320777 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGTGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT81130 NZ_CP023388:c320574-320520 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0GRD6

Antitoxin

Download structure file

References