Detailed information of TA system TA080890

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4409583..4409995
• Replicon: chromosome
• Accession: NZ_CP023357
• Organism: Escherichia coli strain 317

Toxin (Protein)

• Gene name: symE
• Uniprot ID: S1NWQ7
• Locus tag: CNQ55_RS22370
• Protein ID: WP_000132614.1
• Coordinates: 4409654..4409995 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4409583..4409659 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ55_RS22360	4406258..4407727	+	1470	WP_001540814.1	type I restriction-modification system subunit M	-
CNQ55_RS22365	4407727..4409433	+	1707	WP_001100194.1	restriction endonuclease subunit S	-
-	4409583..4409659	-	77	NuclAT_6	-	Antitoxin
-	4409583..4409659	-	77	NuclAT_6	-	Antitoxin
-	4409583..4409659	-	77	NuclAT_6	-	Antitoxin
-	4409583..4409659	-	77	NuclAT_6	-	Antitoxin
-	4409583..4409659	-	77	NuclAT_7	-	Antitoxin
-	4409583..4409659	-	77	NuclAT_7	-	Antitoxin
-	4409583..4409659	-	77	NuclAT_7	-	Antitoxin
-	4409583..4409659	-	77	NuclAT_7	-	Antitoxin
CNQ55_RS22370	4409654..4409995	+	342	WP_000132614.1	endoribonuclease SymE	Toxin
CNQ55_RS22375	4410042..4412135	-	2094	WP_000648237.1	DUF262 domain-containing protein	-
CNQ55_RS22380	4412233..4412313	-	81	WP_020233658.1	hypothetical protein	-
CNQ55_RS22385	4412541..4413461	-	921	WP_000181195.1	Rpn family recombination-promoting nuclease/putative transposase	-
CNQ55_RS22390	4413646..4414926	+	1281	WP_001298033.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	cheD	4393462..4412198	18736

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12266.07 Da
• Isoelectric Point: 8.4982

>T80890 WP_000132614.1 NZ_CP023357:4409654-4409995 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T80890 NZ_CP023357:4409654-4409995 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT80890 NZ_CP023357:c4409659-4409583 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: S1NWQ7

Antitoxin