Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4329484..4329742 Replicon chromosome
Accession NZ_CP023357
Organism Escherichia coli strain 317

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag CNQ55_RS21970 Protein ID WP_000809168.1
Coordinates 4329590..4329742 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4329484..4329541 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ55_RS21950 4325313..4326572 - 1260 WP_000494927.1 hypothetical protein -
CNQ55_RS21955 4326701..4328194 - 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
CNQ55_RS21960 4328214..4328975 - 762 WP_001274828.1 hypothetical protein -
- 4329484..4329541 - 58 - - Antitoxin
CNQ55_RS21970 4329590..4329742 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
CNQ55_RS21975 4329847..4330977 - 1131 WP_001118464.1 molecular chaperone DnaJ -
CNQ55_RS21980 4331066..4332982 - 1917 WP_000516135.1 molecular chaperone DnaK -
CNQ55_RS21985 4333354..4333758 + 405 WP_000843689.1 DUF2541 family protein -
CNQ55_RS21990 4333784..4334497 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T80888 WP_000809168.1 NZ_CP023357:4329590-4329742 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T80888 NZ_CP023357:4329590-4329742 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT80888 NZ_CP023357:c4329541-4329484 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References