Detailed information of TA system TA080629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1560393..1560904
• Replicon: chromosome
• Accession: NZ_CP023202
• Organism: Streptomyces xinghaiensis S187

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: SXIN_RS06580
• Protein ID: WP_019711099.1
• Coordinates: 1560393..1560647 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: SXIN_RS06585
• Protein ID: WP_019711100.1
• Coordinates: 1560644..1560904 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SXIN_RS06555	1555874..1556299	-	426	WP_192883558.1	cell division protein SepF	-
SXIN_RS06560	1556436..1556699	+	264	WP_095756728.1	hypothetical protein	-
SXIN_RS06565	1557035..1557670	-	636	WP_039823564.1	DUF4360 domain-containing protein	-
SXIN_RS06570	1558143..1558487	-	345	WP_019711097.1	hypothetical protein	-
SXIN_RS06575	1558956..1560176	-	1221	WP_039823574.1	transposase	-
SXIN_RS06580	1560393..1560647	-	255	WP_019711099.1	Txe/YoeB family addiction module toxin	Toxin
SXIN_RS06585	1560644..1560904	-	261	WP_019711100.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SXIN_RS06590	1561366..1562178	+	813	WP_019711101.1	DedA family protein	-
SXIN_RS06595	1562349..1563794	+	1446	WP_019711102.1	glyceraldehyde-3-phosphate dehydrogenase	-
SXIN_RS06600	1564176..1564877	+	702	WP_095757953.1	phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10088.37 Da
• Isoelectric Point: 9.3930

>T80629 WP_019711099.1 NZ_CP023202:c1560647-1560393 [Streptomyces xinghaiensis S187]
VKTVFTEHGWADYVHWAETDRRMTRRINRLIEESKRDPFTGIGKPEPLKGDLSGYWSRRIDEEHRLVYRAKGDELVVVQA
RYHY

Nucleotide

• Length: 255 bp

>T80629 NZ_CP023202:c1560647-1560393 [Streptomyces xinghaiensis S187]
GTGAAGACCGTATTCACCGAGCATGGTTGGGCCGACTACGTGCACTGGGCCGAGACGGACCGTCGCATGACCAGGCGCAT
CAATCGGCTCATCGAGGAGAGTAAGCGGGATCCGTTCACCGGCATCGGGAAGCCGGAGCCGCTCAAGGGGGATCTCAGCG
GCTACTGGTCCCGGAGGATCGATGAGGAGCACCGGCTCGTCTACCGGGCCAAAGGTGACGAACTCGTCGTCGTCCAGGCG
CGGTACCACTACTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9624.58 Da
• Isoelectric Point: 4.3246

>AT80629 WP_019711100.1 NZ_CP023202:c1560904-1560644 [Streptomyces xinghaiensis S187]
VSITASEARKNLFRLIENVNDDRSPVHITSRNGNAVLLSEEDFASWQETIYLLRSPANARRLAESIAEAEGGRTEPRELI
EVDDAE

Nucleotide

• Length: 261 bp

>AT80629 NZ_CP023202:c1560904-1560644 [Streptomyces xinghaiensis S187]
GTGTCCATCACCGCCAGTGAAGCCCGAAAGAATCTTTTCCGGTTGATCGAAAACGTCAACGACGATCGGTCTCCGGTGCA
CATCACTTCCCGTAACGGGAATGCCGTGCTGCTGTCCGAGGAGGACTTTGCCTCGTGGCAGGAGACGATCTACCTGCTGC
GGTCGCCGGCCAATGCCCGCCGGTTGGCTGAGTCGATCGCGGAAGCGGAGGGCGGCAGGACGGAGCCCCGAGAGCTGATC
GAGGTCGACGACGCCGAGTGA