Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4340591..4340849 Replicon chromosome
Accession NZ_CP023142
Organism Escherichia coli strain CFSAN061770

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag CA696_RS22530 Protein ID WP_000809168.1
Coordinates 4340697..4340849 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4340591..4340648 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA696_RS22515 4336983..4337942 + 960 WP_000871674.1 hypothetical protein -
CA696_RS22520 4337980..4338879 - 900 WP_001300855.1 transcriptional activator NhaR -
CA696_RS22525 4338945..4340111 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4340591..4340648 - 58 - - Antitoxin
CA696_RS22530 4340697..4340849 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
CA696_RS22535 4340953..4342083 - 1131 WP_001118464.1 molecular chaperone DnaJ -
CA696_RS22540 4342172..4344088 - 1917 WP_000516135.1 molecular chaperone DnaK -
CA696_RS22545 4344464..4344868 + 405 WP_000843584.1 DUF2541 family protein -
CA696_RS22550 4344894..4345607 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T80496 WP_000809168.1 NZ_CP023142:4340697-4340849 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T80496 NZ_CP023142:4340697-4340849 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT80496 NZ_CP023142:c4340648-4340591 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References