Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2677692..2678287 Replicon chromosome
Accession NZ_CP023140
Organism Acinetobacter baumannii strain XH906

Toxin (Protein)


Gene name higB Uniprot ID A0A7M3FN97
Locus tag CK824_RS12785 Protein ID WP_032053387.1
Coordinates 2677692..2677973 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A7M3FNJ1
Locus tag CK824_RS12790 Protein ID WP_032053385.1
Coordinates 2678003..2678287 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CK824_RS12775 2676690..2677070 - 381 Protein_2470 hypothetical protein -
CK824_RS12780 2677193..2677537 - 345 WP_038338750.1 hypothetical protein -
CK824_RS12785 2677692..2677973 + 282 WP_032053387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CK824_RS12790 2678003..2678287 + 285 WP_032053385.1 HigA family addiction module antidote protein Antitoxin
CK824_RS12800 2678578..2679087 - 510 WP_038338755.1 hypothetical protein -
CK824_RS12805 2679158..2680075 - 918 WP_020752401.1 hypothetical protein -
CK824_RS12810 2680170..2681153 - 984 WP_020752400.1 hypothetical protein -
CK824_RS12815 2681153..2681503 - 351 WP_020752399.1 hypothetical protein -
CK824_RS12820 2681599..2681817 - 219 WP_020752398.1 hypothetical protein -
CK824_RS12825 2681819..2682262 - 444 WP_073545229.1 hypothetical protein -
CK824_RS12830 2682219..2682587 - 369 WP_020752396.1 hypothetical protein -
CK824_RS12835 2682559..2682966 - 408 WP_038338740.1 hypothetical protein -
CK824_RS18830 2682979..2683149 - 171 WP_162921993.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2664563..2719704 55141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10651.02 Da        Isoelectric Point: 8.5123

>T80474 WP_032053387.1 NZ_CP023140:2677692-2677973 [Acinetobacter baumannii]
MIKSFKHKGLQAFFEEGSTAGIQAAHSKKLRLLLASLNAATSVYDLRTPPNWRLHELKGNLEGHWSLTVNGNWRVTFKFE
DGDAYIVDYQDYH

Download         Length: 282 bp

>T80474 NZ_CP023140:2677692-2677973 [Acinetobacter baumannii]
TTGATTAAGAGTTTCAAGCATAAGGGGTTGCAAGCTTTCTTTGAAGAAGGCTCAACTGCTGGTATCCAAGCTGCTCACTC
TAAGAAATTACGTTTACTTTTAGCTTCATTGAATGCTGCCACCTCAGTTTATGACTTGAGGACACCACCAAATTGGCGCT
TACATGAATTAAAAGGCAATCTTGAAGGTCATTGGTCTTTAACTGTAAACGGAAATTGGCGTGTAACGTTTAAATTTGAA
GATGGCGATGCATACATCGTGGATTATCAAGATTATCACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10330.89 Da        Isoelectric Point: 7.3174

>AT80474 WP_032053385.1 NZ_CP023140:2678003-2678287 [Acinetobacter baumannii]
MKVMFNAPHPGEILQEYLEGISVTSAARALGVTRANLSRILNGHTGISADMALRLSEALSTSPEFWLNLQVQYDLWIASQ
NKRPTIQHLAPAMA

Download         Length: 285 bp

>AT80474 NZ_CP023140:2678003-2678287 [Acinetobacter baumannii]
ATGAAAGTTATGTTTAATGCACCACACCCTGGCGAAATTCTTCAAGAGTATCTAGAGGGCATTTCAGTTACTAGCGCAGC
ACGAGCATTGGGCGTTACTCGTGCAAACTTATCTCGCATCCTCAATGGCCATACTGGTATATCAGCTGATATGGCGCTTC
GTCTTTCTGAAGCCCTTAGCACCTCACCAGAATTCTGGTTAAACTTGCAAGTACAGTATGATCTTTGGATTGCCAGCCAA
AATAAGCGGCCAACGATTCAGCATTTAGCGCCAGCAATGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M3FN97

Antitoxin

Source ID Structure
AlphaFold DB A0A7M3FNJ1

References