Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2395692..2396209 Replicon chromosome
Accession NZ_CP023076
Organism Staphylococcus argenteus strain XNO62

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7U7PWL3
Locus tag CJ017_RS11840 Protein ID WP_031787172.1
Coordinates 2395692..2395958 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7PWU0
Locus tag CJ017_RS11845 Protein ID WP_031787173.1
Coordinates 2395958..2396209 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ017_RS11815 2391122..2391658 - 537 WP_031787169.1 GNAT family N-acetyltransferase -
CJ017_RS11820 2391891..2392715 - 825 WP_000572040.1 formate/nitrite transporter family protein -
CJ017_RS11825 2392932..2393117 - 186 WP_000230291.1 hypothetical protein -
CJ017_RS11830 2393201..2393668 - 468 WP_031787170.1 SRPBCC domain-containing protein -
CJ017_RS11835 2393851..2395395 - 1545 WP_031787171.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CJ017_RS11840 2395692..2395958 - 267 WP_031787172.1 Txe/YoeB family addiction module toxin Toxin
CJ017_RS11845 2395958..2396209 - 252 WP_031787173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CJ017_RS11850 2396481..2397080 - 600 WP_000162802.1 DsbA family protein -
CJ017_RS11855 2397100..2397462 - 363 WP_031787174.1 DUF4467 domain-containing protein -
CJ017_RS11860 2397716..2398966 + 1251 WP_031787175.1 aminoacyltransferase -
CJ017_RS11865 2399061..2399792 - 732 WP_000615469.1 amino acid ABC transporter ATP-binding protein -
CJ017_RS11870 2399789..2400508 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10511.99 Da        Isoelectric Point: 9.7791

>T80469 WP_031787172.1 NZ_CP023076:c2395958-2395692 [Staphylococcus argenteus]
MARLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALQGIGKPEKLKSNLFGYYSRRINHEHRLVYTVDDNHIK
IASCRYHY

Download         Length: 267 bp

>T80469 NZ_CP023076:c2395958-2395692 [Staphylococcus argenteus]
ATGGCTAGGTTAAACATTACGTTCTCGCCTCAGGCATTTGAAGATTATGAGTATTTTCAGCAGAACGATAAAAAAATGGT
AAAGAAGATTAATGAGTTACTTAAAAGCATTGATAGAAATGGTGCATTGCAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATTTATTTGGCTATTATAGTAGACGTATCAATCACGAACATAGGTTGGTTTATACAGTTGACGATAATCACATAAAA
ATAGCATCCTGTAGATACCATTATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9395.56 Da        Isoelectric Point: 4.3558

>AT80469 WP_031787173.1 NZ_CP023076:c2396209-2395958 [Staphylococcus argenteus]
MIVKNYSYARQNLKTLMTKVNDDSDVVTVTSTDDKNVVIMSEADYNSIIETLYLQQNPNNAEHLAQSIADLERGKMVTKE
IDV

Download         Length: 252 bp

>AT80469 NZ_CP023076:c2396209-2395958 [Staphylococcus argenteus]
ATGATTGTAAAAAACTATTCTTACGCTAGACAGAATTTAAAGACGCTTATGACAAAGGTAAATGACGATAGTGATGTGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATTATGTCAGAAGCAGATTATAATTCTATAATTGAAACCCTTTACC
TTCAACAGAATCCAAATAATGCTGAACACTTAGCCCAATCAATTGCTGACTTAGAACGAGGCAAAATGGTAACGAAAGAA
ATAGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PWL3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7PWU0

References