Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 807957..808521 Replicon chromosome
Accession NZ_CP023057
Organism Glaesserella sp. 15-184

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CJD39_RS03730 Protein ID WP_111749755.1
Coordinates 808243..808521 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CJD39_RS03725 Protein ID WP_111749756.1
Coordinates 807957..808232 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJD39_RS03705 803484..804518 - 1035 WP_111749760.1 ABC transporter substrate-binding protein -
CJD39_RS03710 804659..806149 - 1491 WP_111749759.1 DUF853 domain-containing protein -
CJD39_RS03715 806193..806564 - 372 WP_111749758.1 hypothetical protein -
CJD39_RS03720 806648..807883 - 1236 WP_111749757.1 ATP-dependent RNA helicase RhlB -
CJD39_RS03725 807957..808232 - 276 WP_111749756.1 HigA family addiction module antidote protein Antitoxin
CJD39_RS03730 808243..808521 - 279 WP_111749755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CJD39_RS03735 808660..809676 + 1017 WP_111749754.1 ornithine carbamoyltransferase -
CJD39_RS03740 809846..811108 + 1263 WP_111749753.1 serine hydroxymethyltransferase -
CJD39_RS03745 811165..811443 + 279 WP_111749752.1 DUF1294 domain-containing protein -
CJD39_RS03755 811761..812864 + 1104 WP_111749751.1 murein transglycosylase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10405.81 Da        Isoelectric Point: 7.0726

>T80407 WP_111749755.1 NZ_CP023057:c808521-808243 [Glaesserella sp. 15-184]
MILSFKHKGLKLFFETGSTAGIQANHANRLRLLLTALDAAETALAMSVPGWNLHQLQGDLAGHWSVKVSENWRLTFRFEN
GHAEIVDYQDYH

Download         Length: 279 bp

>T80407 NZ_CP023057:c808521-808243 [Glaesserella sp. 15-184]
ATGATCCTTTCATTTAAGCATAAAGGTTTGAAATTGTTTTTTGAAACAGGCTCAACAGCAGGTATTCAGGCAAATCACGC
TAATAGACTTCGATTACTACTAACTGCTTTAGATGCTGCCGAGACAGCATTAGCAATGAGCGTACCAGGTTGGAATTTAC
ATCAATTACAAGGTGATTTAGCAGGGCATTGGTCTGTTAAAGTTAGCGAAAATTGGCGTTTAACTTTTAGATTTGAAAAT
GGTCACGCTGAAATCGTGGACTATCAAGACTATCATTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10468.16 Da        Isoelectric Point: 9.9359

>AT80407 WP_111749756.1 NZ_CP023057:c808232-807957 [Glaesserella sp. 15-184]
MKMYNPAHPGLILREYIEGYNVTDVAKRLGVTRVTLSRILNGKASISPEMALRLSALLNTTTPQFWLNMQSQYDLWQLEQ
RPSFNIQPLFA

Download         Length: 276 bp

>AT80407 NZ_CP023057:c808232-807957 [Glaesserella sp. 15-184]
ATGAAAATGTACAATCCAGCTCACCCAGGACTAATTTTAAGAGAATATATTGAAGGTTATAATGTTACTGATGTAGCTAA
ACGTTTAGGCGTTACCCGAGTGACACTTTCTCGTATTTTAAACGGCAAAGCGTCTATTTCACCTGAAATGGCATTACGTT
TAAGTGCATTATTAAATACAACAACGCCACAATTTTGGCTCAATATGCAATCACAATACGACCTATGGCAACTTGAGCAA
CGTCCAAGTTTTAATATACAGCCATTATTTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References