Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 27668..28326 Replicon plasmid pAba7847b
Accession NZ_CP023033
Organism Acinetobacter baumannii strain 7847

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Aba7847_RS19495 Protein ID WP_000312250.1
Coordinates 27668..28027 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Aba7847_RS19500 Protein ID WP_001096429.1
Coordinates 28027..28326 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aba7847_RS19460 23189..23503 - 315 WP_000708714.1 hypothetical protein -
Aba7847_RS19470 24559..25317 - 759 WP_001053127.1 hypothetical protein -
Aba7847_RS19475 25384..25767 - 384 WP_000654348.1 hypothetical protein -
Aba7847_RS19480 25905..26603 - 699 WP_000873188.1 hypothetical protein -
Aba7847_RS19485 26670..26852 - 183 WP_000373385.1 hypothetical protein -
Aba7847_RS19490 26901..27467 - 567 WP_000710385.1 hypothetical protein -
Aba7847_RS19495 27668..28027 + 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Aba7847_RS19500 28027..28326 + 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
Aba7847_RS19510 28864..29400 - 537 WP_000731978.1 hypothetical protein -
Aba7847_RS19515 29450..30004 - 555 WP_000790084.1 hypothetical protein -
Aba7847_RS19520 30024..30242 - 219 WP_001043201.1 hypothetical protein -
Aba7847_RS19525 30282..30911 - 630 WP_000701003.1 hypothetical protein -
Aba7847_RS19530 30928..31107 - 180 WP_000387630.1 hypothetical protein -
Aba7847_RS19535 31083..31655 - 573 WP_000443897.1 hypothetical protein -
Aba7847_RS19540 31660..31917 - 258 WP_000834290.1 hypothetical protein -
Aba7847_RS19545 32022..33302 - 1281 WP_063558595.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..80546 80546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-109)

Antitoxin

(12-88)


Sequences


Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T80352 WP_000312250.1 NZ_CP023033:27668-28027 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T80352 NZ_CP023033:27668-28027 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT80352 WP_001096429.1 NZ_CP023033:28027-28326 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT80352 NZ_CP023033:28027-28326 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References