Detailed information of TA system TA080349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 34163..34821
• Replicon: plasmid pAba9102a
• Accession: NZ_CP023030
• Organism: Acinetobacter baumannii strain 9102

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: Aba9102_RS19415
• Protein ID: WP_000312250.1
• Coordinates: 34462..34821 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Aba9102_RS19410
• Protein ID: WP_001096429.1
• Coordinates: 34163..34462 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba9102_RS19365	29187..30467	+	1281	WP_063558595.1	hypothetical protein	-
Aba9102_RS19370	30572..30829	+	258	WP_000834290.1	hypothetical protein	-
Aba9102_RS19375	30834..31406	+	573	WP_000443897.1	hypothetical protein	-
Aba9102_RS19380	31382..31561	+	180	WP_000387630.1	hypothetical protein	-
Aba9102_RS19385	31578..32207	+	630	WP_000701003.1	hypothetical protein	-
Aba9102_RS19390	32247..32465	+	219	WP_001043201.1	hypothetical protein	-
Aba9102_RS19395	32485..33039	+	555	WP_000790084.1	hypothetical protein	-
Aba9102_RS19400	33089..33625	+	537	WP_000731978.1	hypothetical protein	-
Aba9102_RS19410	34163..34462	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
Aba9102_RS19415	34462..34821	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Aba9102_RS19420	35022..35588	+	567	WP_000710385.1	hypothetical protein	-
Aba9102_RS19425	35637..35819	+	183	WP_000373385.1	hypothetical protein	-
Aba9102_RS19430	35886..36584	+	699	WP_000873188.1	hypothetical protein	-
Aba9102_RS19435	36722..37105	+	384	WP_000654348.1	hypothetical protein	-
Aba9102_RS19440	37172..37930	+	759	WP_001053127.1	hypothetical protein	-
Aba9102_RS19450	38986..39300	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aph(3')-VIa	-	1..95206	95206

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T80349 WP_000312250.1 NZ_CP023030:c34821-34462 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T80349 NZ_CP023030:c34821-34462 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT80349 WP_001096429.1 NZ_CP023030:c34462-34163 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT80349 NZ_CP023030:c34462-34163 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA