Detailed information of TA system TA080346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 30680..31338
• Replicon: plasmid pAba10042b
• Accession: NZ_CP023028
• Organism: Acinetobacter baumannii strain 10042

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: Aba10042_RS19875
• Protein ID: WP_000312250.1
• Coordinates: 30979..31338 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Aba10042_RS19870
• Protein ID: WP_001096429.1
• Coordinates: 30680..30979 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba10042_RS19825	25703..26983	+	1281	WP_063558595.1	hypothetical protein	-
Aba10042_RS19830	27088..27345	+	258	WP_000834290.1	hypothetical protein	-
Aba10042_RS19835	27350..27922	+	573	WP_000443897.1	hypothetical protein	-
Aba10042_RS19840	27898..28077	+	180	WP_000387630.1	hypothetical protein	-
Aba10042_RS19845	28094..28723	+	630	WP_000701003.1	hypothetical protein	-
Aba10042_RS19850	28763..28981	+	219	WP_001043201.1	hypothetical protein	-
Aba10042_RS19855	29001..29555	+	555	WP_000790084.1	hypothetical protein	-
Aba10042_RS19860	29605..30141	+	537	WP_000731978.1	hypothetical protein	-
Aba10042_RS19870	30680..30979	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
Aba10042_RS19875	30979..31338	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Aba10042_RS19880	31539..32105	+	567	WP_000710385.1	hypothetical protein	-
Aba10042_RS19885	32154..32336	+	183	WP_000373385.1	hypothetical protein	-
Aba10042_RS19890	32403..33101	+	699	WP_000873188.1	hypothetical protein	-
Aba10042_RS19895	33239..33622	+	384	WP_000654348.1	hypothetical protein	-
Aba10042_RS19900	33689..34447	+	759	WP_001053127.1	hypothetical protein	-
Aba10042_RS19910	35503..35817	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aph(3')-VIa	-	1..110728	110728

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T80346 WP_000312250.1 NZ_CP023028:c31338-30979 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T80346 NZ_CP023028:c31338-30979 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT80346 WP_001096429.1 NZ_CP023028:c30979-30680 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT80346 NZ_CP023028:c30979-30680 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA