Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3616936..3617596 Replicon chromosome
Accession NZ_CP023009
Organism Lonsdalea britannica strain 477

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CKQ53_RS16600 Protein ID WP_085650943.1
Coordinates 3617243..3617596 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKQ53_RS16595 Protein ID WP_085650942.1
Coordinates 3616936..3617238 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKQ53_RS16575 3612826..3613656 - 831 WP_094117440.1 ABC transporter permease -
CKQ53_RS16580 3613595..3614374 - 780 WP_094117439.1 ABC transporter ATP-binding protein -
CKQ53_RS16585 3614409..3615446 - 1038 WP_118895194.1 ABC transporter substrate-binding protein -
CKQ53_RS16590 3615487..3616419 - 933 WP_085650941.1 MurR/RpiR family transcriptional regulator -
CKQ53_RS16595 3616936..3617238 - 303 WP_085650942.1 XRE family transcriptional regulator Antitoxin
CKQ53_RS16600 3617243..3617596 - 354 WP_085650943.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKQ53_RS16605 3618018..3619472 - 1455 WP_094117438.1 sugar porter family MFS transporter -
CKQ53_RS18595 3619888..3620046 + 159 WP_176223437.1 hypothetical protein -
CKQ53_RS16615 3620181..3621188 + 1008 WP_094117437.1 alpha/beta hydrolase -
CKQ53_RS16620 3621352..3622302 + 951 WP_208640017.1 D-2-hydroxyacid dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13708.95 Da        Isoelectric Point: 8.8419

>T80330 WP_085650943.1 NZ_CP023009:c3617596-3617243 [Lonsdalea britannica]
VWVIETTETFDVWFCSLCDIDRACVLAALMVLREKGPMLPRPYVDTVKRSRYSNMKELRVQSRGDPIRAFFAFDPRRTGI
LLCAGNKAGHEKRFYDEMIPLADREFTKYLNQLNKKE

Download         Length: 354 bp

>T80330 NZ_CP023009:c3617596-3617243 [Lonsdalea britannica]
GTGTGGGTCATTGAAACAACAGAAACATTTGACGTTTGGTTTTGTTCGTTATGCGATATCGACCGGGCCTGCGTACTTGC
GGCGCTCATGGTGTTGCGGGAAAAGGGACCGATGTTGCCAAGACCCTACGTCGATACAGTCAAACGTTCCCGCTACAGCA
ATATGAAAGAGCTGAGAGTGCAAAGCCGGGGGGATCCCATACGCGCTTTTTTCGCCTTTGACCCGCGCCGTACCGGTATT
CTGCTGTGTGCAGGCAATAAGGCTGGTCATGAAAAGCGCTTTTACGATGAGATGATCCCGCTGGCCGATCGAGAATTCAC
GAAGTATCTCAATCAATTAAATAAGAAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11057.84 Da        Isoelectric Point: 6.4727

>AT80330 WP_085650942.1 NZ_CP023009:c3617238-3616936 [Lonsdalea britannica]
MGRTLEQLIADEKPEVVADAQTIAADMLLNIHLAELREKVQKTQVEMAQALGLKQPTVAGMEKRGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT80330 NZ_CP023009:c3617238-3616936 [Lonsdalea britannica]
ATGGGTAGAACGCTGGAACAGCTTATCGCGGATGAAAAACCGGAAGTCGTCGCGGATGCGCAGACCATCGCCGCGGATAT
GCTGCTCAATATTCACCTCGCGGAACTGCGCGAGAAAGTACAGAAAACGCAGGTAGAAATGGCGCAGGCGCTGGGACTGA
AACAGCCGACCGTCGCGGGGATGGAGAAACGAGGCCGGGACTTGAAGCTGTCTACGCTTAAACGCTATGTCGAGGCAACC
GGCGGCAAGCTGCGGCTTGATGTCGAACTGCCGGACGGCTCGCACTACGGTTTTGTGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References