Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2377651..2378251 Replicon chromosome
Accession NZ_CP022987
Organism Pusillimonas thiosulfatoxidans strain YE3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CKA81_RS11455 Protein ID WP_128355399.1
Coordinates 2377651..2377962 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKA81_RS11460 Protein ID WP_128355400.1
Coordinates 2377964..2378251 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKA81_RS11435 2373438..2374517 - 1080 WP_128355396.1 peptide chain release factor 1 -
CKA81_RS11440 2374584..2375858 - 1275 WP_128355397.1 glutamyl-tRNA reductase -
CKA81_RS11450 2376277..2377590 + 1314 WP_128355398.1 integrase arm-type DNA-binding domain-containing protein -
CKA81_RS11455 2377651..2377962 + 312 WP_128355399.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKA81_RS11460 2377964..2378251 + 288 WP_128355400.1 helix-turn-helix domain-containing protein Antitoxin
CKA81_RS11465 2378327..2378617 + 291 WP_128355401.1 hypothetical protein -
CKA81_RS11470 2378669..2379340 + 672 WP_128355402.1 conjugal transfer protein TrbM -
CKA81_RS11475 2379351..2380016 + 666 WP_128355403.1 lytic transglycosylase domain-containing protein -
CKA81_RS11480 2380100..2380420 + 321 WP_128355404.1 TrbC/VirB2 family protein -
CKA81_RS11485 2380424..2380744 + 321 WP_128355405.1 VirB3 family type IV secretion system protein -
CKA81_RS11490 2380756..2383199 + 2444 Protein_2246 VirB4 family type IV secretion/conjugal transfer ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-79)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11666.54 Da        Isoelectric Point: 5.8505

>T80290 WP_128355399.1 NZ_CP022987:2377651-2377962 [Pusillimonas thiosulfatoxidans]
MEFIETPLFTRQIVDLLPDDDYAELQQILAANPRRGDLIPSGGGIRKVRHARPGMGKSGGIRVIYYWITAEDQIMMLLAY
PKSKQENLTPAQIEELRALVKDL

Download         Length: 312 bp

>T80290 NZ_CP022987:2377651-2377962 [Pusillimonas thiosulfatoxidans]
ATGGAATTCATCGAAACTCCCCTGTTCACTCGACAAATCGTAGACTTGCTTCCAGACGATGACTACGCTGAACTGCAACA
GATTTTGGCTGCTAACCCTCGGCGGGGTGATCTGATTCCGTCTGGAGGAGGAATCCGAAAGGTACGTCATGCAAGACCAG
GAATGGGGAAAAGTGGCGGCATTCGTGTCATCTACTACTGGATCACTGCCGAAGATCAAATCATGATGCTCCTGGCTTAT
CCGAAGTCGAAACAGGAGAATCTGACCCCCGCACAGATTGAGGAACTGCGGGCATTGGTAAAGGACCTCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10415.93 Da        Isoelectric Point: 10.5848

>AT80290 WP_128355400.1 NZ_CP022987:2377964-2378251 [Pusillimonas thiosulfatoxidans]
MDTELFEDLKESLRQAKAIRAGELEGRRTTVSPIDVRAVRESTKLSQGEFAAAINVSVRTLQNWEQHRRSPTGPAAALLK
VMAAAPATVIKALHH

Download         Length: 288 bp

>AT80290 NZ_CP022987:2377964-2378251 [Pusillimonas thiosulfatoxidans]
ATGGACACAGAACTCTTTGAAGACCTAAAAGAAAGCCTGCGGCAAGCCAAGGCCATCCGCGCAGGCGAGCTCGAAGGCCG
CCGCACTACCGTCAGCCCCATTGACGTCAGGGCCGTGCGCGAAAGCACGAAGCTCTCGCAAGGCGAGTTTGCTGCAGCCA
TCAACGTCAGCGTGCGTACACTACAGAATTGGGAGCAACACCGGCGATCTCCTACCGGCCCAGCCGCCGCCCTGCTGAAA
GTCATGGCAGCGGCTCCAGCCACCGTCATCAAAGCCCTACATCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References