Detailed information of TA system TA080285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1717125..1717628
• Replicon: chromosome
• Accession: NZ_CP022985
• Organism: Mariniflexile sp. TRM1-10

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CJ739_RS07420
• Protein ID: WP_117173923.1
• Coordinates: 1717125..1717379 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CJ739_RS07425
• Protein ID: WP_117173925.1
• Coordinates: 1717380..1717628 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJ739_RS07405	1712396..1713403	-	1008	WP_117173917.1	DUF4837 family protein	-
CJ739_RS07410	1713429..1714952	-	1524	WP_117173919.1	lytic transglycosylase domain-containing protein	-
CJ739_RS07415	1715427..1716614	-	1188	WP_117173921.1	phosphoglycerate kinase	-
CJ739_RS07420	1717125..1717379	-	255	WP_117173923.1	Txe/YoeB family addiction module toxin	Toxin
CJ739_RS07425	1717380..1717628	-	249	WP_117173925.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CJ739_RS07430	1718240..1719394	+	1155	WP_117173927.1	DNA polymerase III subunit delta'	-
CJ739_RS07435	1719462..1719977	-	516	WP_117173929.1	OmpH family outer membrane protein	-
CJ739_RS07440	1720205..1721065	-	861	WP_117173931.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10105.63 Da
• Isoelectric Point: 9.5666

>T80285 WP_117173923.1 NZ_CP022985:c1717379-1717125 [Mariniflexile sp. TRM1-10]
MKLTWSTSSWEDYLYWQKVDKKIVKRINELIKSAMRTPFDGIGKPESLKGGLQGYWSRRITSEHRLVYKYEDEEILIAAC
RYHY

Nucleotide

• Length: 255 bp

>T80285 NZ_CP022985:c1717379-1717125 [Mariniflexile sp. TRM1-10]
ATGAAGTTAACTTGGTCCACTTCTTCTTGGGAAGATTATTTGTATTGGCAAAAAGTCGACAAGAAGATTGTAAAACGCAT
TAATGAACTGATTAAAAGTGCAATGCGAACACCTTTTGACGGCATAGGAAAACCCGAGTCTTTAAAAGGCGGTTTACAGG
GCTATTGGTCAAGGAGAATAACATCGGAACATCGATTGGTCTATAAATACGAAGATGAAGAAATCCTGATAGCAGCCTGT
CGTTATCATTACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9504.88 Da
• Isoelectric Point: 5.8430

>AT80285 WP_117173925.1 NZ_CP022985:c1717628-1717380 [Mariniflexile sp. TRM1-10]
METVNYTDFRSNLKHWFDKVVNDVSDIVIKRKNGKDLVLISLDEYNSLKETTYLLTGKNRDILLNSIKELEAGKGVQKDL
ME

Nucleotide

• Length: 249 bp

>AT80285 NZ_CP022985:c1717628-1717380 [Mariniflexile sp. TRM1-10]
ATGGAAACAGTAAATTATACAGACTTTCGTTCAAATCTAAAGCATTGGTTCGATAAAGTGGTCAATGATGTAAGCGATAT
CGTTATCAAGCGTAAAAACGGTAAAGACCTCGTATTGATATCATTGGACGAATACAACTCATTAAAGGAAACGACGTATC
TGTTAACAGGAAAGAATAGGGATATTTTATTGAACTCTATCAAAGAACTGGAAGCAGGCAAAGGCGTTCAAAAAGACTTA
ATGGAATAG