Detailed information of TA system TA080280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3687068..3687768
• Replicon: chromosome
• Accession: NZ_CP022962
• Organism: Bordetella bronchiseptica strain KM22

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0H3LPJ8
• Locus tag: CJ015_RS17315
• Protein ID: WP_003809515.1
• Coordinates: 3687472..3687768 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: CJ015_RS17310
• Protein ID: WP_003809516.1
• Coordinates: 3687068..3687469 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJ015_RS17280	3682247..3683275	-	1029	WP_033447398.1	amino acid ABC transporter substrate-binding protein	-
CJ015_RS17285	3683412..3684449	-	1038	WP_033451923.1	threonylcarbamoyl-AMP synthase	-
CJ015_RS17290	3684469..3685659	-	1191	WP_003809527.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
CJ015_RS17295	3685662..3686177	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CJ015_RS17300	3686325..3686804	-	480	WP_003809523.1	disulfide bond formation protein B	-
CJ015_RS17305	3686812..3687048	-	237	WP_003809519.1	hypothetical protein	-
CJ015_RS17310	3687068..3687469	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CJ015_RS17315	3687472..3687768	-	297	WP_003809515.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CJ015_RS17320	3688051..3688932	-	882	WP_033451921.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CJ015_RS17325	3689158..3689604	+	447	WP_033451920.1	GFA family protein	-
CJ015_RS17330	3689690..3690754	-	1065	WP_033451323.1	fructose-bisphosphate aldolase class II	-
CJ015_RS17335	3690930..3691472	-	543	WP_003809508.1	MOSC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10608.50 Da
• Isoelectric Point: 7.9291

>T80280 WP_003809515.1 NZ_CP022962:c3687768-3687472 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Nucleotide

• Length: 297 bp

>T80280 NZ_CP022962:c3687768-3687472 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTTCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT80280 WP_003809516.1 NZ_CP022962:c3687469-3687068 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT80280 NZ_CP022962:c3687469-3687068 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCCCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Toxin

• AlphaFold DB: A0A0H3LPJ8

Antitoxin

• AlphaFold DB: A0A0H3LKS6