Detailed information of TA system TA080271

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4072239..4072651
• Replicon: chromosome
• Accession: NZ_CP022959
• Organism: Escherichia coli ATCC 8739

Toxin (Protein)

• Gene name: symE
• Uniprot ID: B1IS82
• Locus tag: CJZ69_RS20250
• Protein ID: WP_000132625.1
• Coordinates: 4072310..4072651 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4072239..4072315 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJZ69_RS20240	4069670..4070332	+	663	Protein_3828	N-6 DNA methylase	-
CJZ69_RS20245	4070332..4072089	+	1758	WP_000110077.1	restriction endonuclease subunit S	-
-	4072239..4072315	-	77	NuclAT_12	-	Antitoxin
-	4072239..4072315	-	77	NuclAT_12	-	Antitoxin
-	4072239..4072315	-	77	NuclAT_12	-	Antitoxin
-	4072239..4072315	-	77	NuclAT_12	-	Antitoxin
-	4072239..4072315	-	77	NuclAT_13	-	Antitoxin
-	4072239..4072315	-	77	NuclAT_13	-	Antitoxin
-	4072239..4072315	-	77	NuclAT_13	-	Antitoxin
-	4072239..4072315	-	77	NuclAT_13	-	Antitoxin
CJZ69_RS20250	4072310..4072651	+	342	WP_000132625.1	endoribonuclease SymE	Toxin
CJZ69_RS20255	4072698..4074791	-	2094	WP_000648226.1	DUF262 domain-containing protein	-
CJZ69_RS20260	4074888..4075052	-	165	WP_000394276.1	DUF1127 domain-containing protein	-
CJZ69_RS20265	4075229..4076641	+	1413	WP_000199353.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12270.10 Da
• Isoelectric Point: 8.4952

>T80271 WP_000132625.1 NZ_CP022959:4072310-4072651 [Escherichia coli ATCC 8739]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVVVKVMEGCIVLTAQPAAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T80271 NZ_CP022959:4072310-4072651 [Escherichia coli ATCC 8739]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGTTGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCCGCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT80271 NZ_CP022959:c4072315-4072239 [Escherichia coli ATCC 8739]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: B1IS82

Antitoxin