Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2464765..2465282 Replicon chromosome
Accession NZ_CP022910
Organism Staphylococcus aureus strain 164

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag CGP88_RS13005 Protein ID WP_000113262.1
Coordinates 2464765..2465031 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CGP88_RS13010 Protein ID WP_115285425.1
Coordinates 2465031..2465282 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP88_RS12975 2460191..2460727 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
CGP88_RS12980 2460960..2461784 - 825 WP_000572040.1 formate/nitrite transporter family protein -
CGP88_RS12985 2462001..2462183 - 183 WP_000230294.1 hypothetical protein -
CGP88_RS12990 2462267..2462734 - 468 WP_000153344.1 SRPBCC domain-containing protein -
CGP88_RS12995 2462920..2464470 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CGP88_RS13000 2464659..2464730 - 72 Protein_2401 hypothetical protein -
CGP88_RS13005 2464765..2465031 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
CGP88_RS13010 2465031..2465282 - 252 WP_115285425.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CGP88_RS13015 2465447..2465548 - 102 WP_001791744.1 hypothetical protein -
CGP88_RS13020 2465555..2466154 - 600 WP_000162813.1 DsbA family protein -
CGP88_RS13025 2466173..2466535 - 363 WP_000819843.1 DUF4467 domain-containing protein -
CGP88_RS13030 2466790..2468040 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
CGP88_RS13035 2468137..2468868 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CGP88_RS13040 2468865..2469584 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T80124 WP_000113262.1 NZ_CP022910:c2465031-2464765 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T80124 NZ_CP022910:c2465031-2464765 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9415.57 Da        Isoelectric Point: 4.3407

>AT80124 WP_115285425.1 NZ_CP022910:c2465282-2465031 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT80124 NZ_CP022910:c2465282-2465031 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATTGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure

References