Detailed information of TA system TA080123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2199760..2199977
• Replicon: chromosome
• Accession: NZ_CP022910
• Organism: Staphylococcus aureus strain 164

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: CGP88_RS11580
• Protein ID: WP_001802298.1
• Coordinates: 2199873..2199977 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2199760..2199815 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP88_RS11560	2195897..2196562	-	666	WP_001024094.1	SDR family oxidoreductase	-
CGP88_RS11565	2196714..2197034	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
CGP88_RS11570	2197036..2198016	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
CGP88_RS11575	2198282..2199373	+	1092	WP_115285413.1	transcriptional regulator	-
-	2199760..2199815	+	56	-	-	Antitoxin
CGP88_RS11580	2199873..2199977	-	105	WP_001802298.1	hypothetical protein	Toxin
CGP88_RS14920	2200138..2200621	-	484	Protein_2135	recombinase family protein	-
CGP88_RS11590	2200664..2201800	-	1137	WP_000115564.1	SAP domain-containing protein	-
CGP88_RS11595	2202089..2202181	+	93	WP_001790138.1	hypothetical protein	-
CGP88_RS11600	2202886..2203743	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
CGP88_RS11605	2203811..2204593	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T80123 WP_001802298.1 NZ_CP022910:c2199977-2199873 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T80123 NZ_CP022910:c2199977-2199873 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT80123 NZ_CP022910:2199760-2199815 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin