Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2047723..2048137 Replicon chromosome
Accession NZ_CP022910
Organism Staphylococcus aureus strain 164

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CGP88_RS10680 Protein ID WP_001065064.1
Coordinates 2047886..2048137 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CGP88_RS14980 Protein ID WP_000028424.1
Coordinates 2047723..2047896 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP88_RS10625 2043935..2044402 - 468 Protein_1956 phage terminase small subunit P27 family -
CGP88_RS10630 2044531..2044875 - 345 WP_000817289.1 HNH endonuclease -
CGP88_RS10635 2044891..2045343 - 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
CGP88_RS10640 2045458..2045928 - 471 WP_115285404.1 hypothetical protein -
CGP88_RS10650 2045951..2046151 - 201 WP_000265041.1 DUF1514 family protein -
CGP88_RS10655 2046151..2046300 - 150 WP_000595265.1 transcriptional activator RinB -
CGP88_RS10660 2046297..2046503 - 207 WP_000195759.1 DUF1381 domain-containing protein -
CGP88_RS10665 2046520..2046693 - 174 WP_001209216.1 hypothetical protein -
CGP88_RS10670 2046730..2047263 - 534 WP_115285405.1 dUTP diphosphatase -
CGP88_RS14975 2047278..2047439 - 162 WP_000889682.1 hypothetical protein -
CGP88_RS14980 2047723..2047896 - 174 WP_000028424.1 hypothetical protein Antitoxin
CGP88_RS10680 2047886..2048137 - 252 WP_001065064.1 DUF1024 family protein Toxin
CGP88_RS10685 2048130..2048414 - 285 WP_115285406.1 hypothetical protein -
CGP88_RS10690 2048411..2048860 - 450 WP_000982708.1 hypothetical protein -
CGP88_RS10695 2048857..2049051 - 195 WP_115285407.1 hypothetical protein -
CGP88_RS10700 2049048..2049452 - 405 WP_000695756.1 hypothetical protein -
CGP88_RS10705 2049455..2049661 - 207 WP_000693989.1 hypothetical protein -
CGP88_RS10710 2049675..2049923 - 249 WP_031765532.1 phi PVL orf 51-like protein -
CGP88_RS10715 2049924..2050541 - 618 WP_115285408.1 hypothetical protein -
CGP88_RS10720 2050542..2050727 - 186 WP_001187266.1 DUF3113 family protein -
CGP88_RS10725 2050732..2051136 - 405 WP_001662752.1 DUF1064 domain-containing protein -
CGP88_RS10730 2051147..2051368 - 222 WP_001662751.1 DUF3269 family protein -
CGP88_RS10735 2051381..2051539 - 159 WP_000628834.1 hypothetical protein -
CGP88_RS10740 2051536..2052321 - 786 WP_031784403.1 ATP-binding protein -
CGP88_RS10745 2052334..2053095 - 762 WP_049881739.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / groEL 2020615..2076561 55946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T80119 WP_001065064.1 NZ_CP022910:c2048137-2047886 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T80119 NZ_CP022910:c2048137-2047886 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGAATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT80119 WP_000028424.1 NZ_CP022910:c2047896-2047723 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT80119 NZ_CP022910:c2047896-2047723 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References