Detailed information of TA system TA080115

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2024255..2024554
• Replicon: chromosome
• Accession: NZ_CP022910
• Organism: Staphylococcus aureus strain 164

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: CGP88_RS10525
• Protein ID: WP_072353918.1
• Coordinates: 2024378..2024554 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2024255..2024310 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP88_RS10470	2019812..2019991	+	180	WP_000669789.1	hypothetical protein	-
CGP88_RS10480	2020302..2020562	+	261	WP_001791826.1	hypothetical protein	-
CGP88_RS10485	2020615..2020965	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
CGP88_RS10490	2021476..2021810	-	335	Protein_1931	SH3 domain-containing protein	-
CGP88_RS10505	2022463..2022954	-	492	WP_000920041.1	staphylokinase	-
CGP88_RS10510	2023145..2023900	-	756	WP_000861038.1	CHAP domain-containing protein	-
CGP88_RS10515	2023912..2024166	-	255	WP_000611512.1	phage holin	-
CGP88_RS10520	2024218..2024325	+	108	WP_001791821.1	hypothetical protein	-
-	2024247..2024386	+	140	NuclAT_0	-	-
-	2024247..2024386	+	140	NuclAT_0	-	-
-	2024247..2024386	+	140	NuclAT_0	-	-
-	2024247..2024386	+	140	NuclAT_0	-	-
-	2024255..2024310	+	56	-	-	Antitoxin
CGP88_RS10525	2024378..2024554	-	177	WP_072353918.1	putative holin-like toxin	Toxin
CGP88_RS10530	2024697..2025071	-	375	WP_000340977.1	hypothetical protein	-
CGP88_RS10535	2025127..2025414	-	288	WP_001262620.1	hypothetical protein	-
CGP88_RS10540	2025460..2025612	-	153	WP_001000058.1	hypothetical protein	-
CGP88_RS10545	2025605..2029387	-	3783	WP_000582132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2020615..2076561	55946

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T80115 WP_072353918.1 NZ_CP022910:c2024554-2024378 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T80115 NZ_CP022910:c2024554-2024378 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT80115 NZ_CP022910:2024255-2024310 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin