Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2082281..2082704 Replicon chromosome
Accession NZ_CP022908
Organism Staphylococcus aureus strain 545

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag CGQ00_RS10990 Protein ID WP_001065110.1
Coordinates 2082453..2082704 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag CGQ00_RS10985 Protein ID WP_000028425.1
Coordinates 2082281..2082463 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ00_RS10945 2077674..2077964 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
CGQ00_RS10950 2078098..2078202 + 105 WP_015978074.1 hypothetical protein -
CGQ00_RS10955 2078305..2080752 - 2448 WP_115276637.1 virulence-associated E family protein -
CGQ00_RS10960 2080805..2081005 - 201 WP_000265258.1 DUF1514 family protein -
CGQ00_RS10965 2081073..2081225 - 153 WP_000595237.1 transcriptional activator RinB -
CGQ00_RS10970 2081218..2081454 - 237 WP_000483477.1 hypothetical protein -
CGQ00_RS10975 2081479..2081715 - 237 WP_000195806.1 DUF1381 domain-containing protein -
CGQ00_RS10980 2081752..2082288 - 537 WP_000185703.1 dUTPase -
CGQ00_RS10985 2082281..2082463 - 183 WP_000028425.1 hypothetical protein Antitoxin
CGQ00_RS10990 2082453..2082704 - 252 WP_001065110.1 DUF1024 family protein Toxin
CGQ00_RS10995 2082719..2082967 - 249 WP_000177805.1 phi PVL orf 51-like protein -
CGQ00_RS11000 2082967..2083221 - 255 WP_000111495.1 DUF3310 domain-containing protein -
CGQ00_RS11005 2083221..2083580 - 360 WP_000117792.1 hypothetical protein -
CGQ00_RS11010 2083581..2083766 - 186 WP_001187264.1 DUF3113 family protein -
CGQ00_RS11015 2083766..2084173 - 408 WP_000401950.1 RusA family crossover junction endodeoxyribonuclease -
CGQ00_RS11020 2084183..2084404 - 222 WP_001123684.1 DUF3269 family protein -
CGQ00_RS11025 2084417..2084575 - 159 WP_000628839.1 hypothetical protein -
CGQ00_RS11030 2084572..2085357 - 786 WP_114647922.1 ATP-binding protein -
CGQ00_RS11035 2085370..2086125 - 756 WP_115284618.1 helix-turn-helix domain-containing protein -
CGQ00_RS11045 2086190..2086471 + 282 WP_000414755.1 hypothetical protein -
CGQ00_RS15840 2086464..2086613 - 150 WP_001081076.1 hypothetical protein -
CGQ00_RS11050 2086610..2087284 - 675 WP_031928974.1 phi PV83 orf 19-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2051693..2096277 44584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T80100 WP_001065110.1 NZ_CP022908:c2082704-2082453 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T80100 NZ_CP022908:c2082704-2082453 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT80100 WP_000028425.1 NZ_CP022908:c2082463-2082281 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT80100 NZ_CP022908:c2082463-2082281 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References