Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1957048..1957230 Replicon chromosome
Accession NZ_CP022908
Organism Staphylococcus aureus strain 545

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag CGQ00_RS10135 Protein ID WP_001801861.1
Coordinates 1957048..1957143 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1957171..1957230 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ00_RS10085 1952708..1953334 + 627 WP_000669046.1 hypothetical protein -
CGQ00_RS10090 1953375..1953719 + 345 WP_000627551.1 DUF3969 family protein -
CGQ00_RS10095 1953817..1954368 + 552 WP_000414205.1 hypothetical protein -
CGQ00_RS10100 1954586..1955227 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
CGQ00_RS10105 1955341..1955526 - 186 WP_000809857.1 hypothetical protein -
CGQ00_RS10110 1955528..1955704 - 177 WP_000375476.1 hypothetical protein -
CGQ00_RS10115 1955715..1956098 - 384 WP_000070811.1 hypothetical protein -
CGQ00_RS10125 1956702..1956845 - 144 WP_001549059.1 transposase -
CGQ00_RS10135 1957048..1957143 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1957171..1957230 - 60 - - Antitoxin
CGQ00_RS10140 1957266..1957367 + 102 WP_001791893.1 hypothetical protein -
CGQ00_RS10145 1957345..1957521 - 177 Protein_1907 transposase -
CGQ00_RS10150 1957715..1958092 - 378 WP_001037045.1 DUF1433 domain-containing protein -
CGQ00_RS10155 1958613..1959440 - 828 Protein_1909 ATP-binding protein -
CGQ00_RS10160 1959490..1960662 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1931133..1977091 45958
- flank IS/Tn - - 1959490..1960662 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T80097 WP_001801861.1 NZ_CP022908:1957048-1957143 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T80097 NZ_CP022908:1957048-1957143 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT80097 NZ_CP022908:c1957230-1957171 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References