Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1618665..1619088 Replicon chromosome
Accession NZ_CP022908
Organism Staphylococcus aureus strain 545

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag CGQ00_RS08345 Protein ID WP_001065110.1
Coordinates 1618837..1619088 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag CGQ00_RS08340 Protein ID WP_000028425.1
Coordinates 1618665..1618847 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ00_RS08300 1614058..1614348 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
CGQ00_RS08305 1614482..1614586 + 105 WP_015978074.1 hypothetical protein -
CGQ00_RS08310 1614689..1617136 - 2448 WP_115276637.1 virulence-associated E family protein -
CGQ00_RS08315 1617189..1617389 - 201 WP_000265258.1 DUF1514 family protein -
CGQ00_RS08320 1617457..1617609 - 153 WP_000595237.1 transcriptional activator RinB -
CGQ00_RS08325 1617602..1617838 - 237 WP_000483477.1 hypothetical protein -
CGQ00_RS08330 1617863..1618099 - 237 WP_000195806.1 DUF1381 domain-containing protein -
CGQ00_RS08335 1618136..1618672 - 537 WP_000185703.1 dUTPase -
CGQ00_RS08340 1618665..1618847 - 183 WP_000028425.1 hypothetical protein Antitoxin
CGQ00_RS08345 1618837..1619088 - 252 WP_001065110.1 DUF1024 family protein Toxin
CGQ00_RS08350 1619103..1619345 - 243 WP_000132193.1 hypothetical protein -
CGQ00_RS08355 1619360..1619560 - 201 WP_000235324.1 hypothetical protein -
CGQ00_RS08360 1619563..1619820 - 258 WP_000022728.1 DUF3310 domain-containing protein -
CGQ00_RS08365 1619820..1620221 - 402 WP_031776133.1 phage DNA polymerase -
CGQ00_RS08370 1620221..1620406 - 186 WP_001164629.1 DUF3113 family protein -
CGQ00_RS08375 1620419..1622371 - 1953 WP_001802096.1 DNA polymerase -
CGQ00_RS08380 1622439..1622996 - 558 WP_000645045.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1585051..1649345 64294


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T80093 WP_001065110.1 NZ_CP022908:c1619088-1618837 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T80093 NZ_CP022908:c1619088-1618837 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT80093 WP_000028425.1 NZ_CP022908:c1618847-1618665 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT80093 NZ_CP022908:c1618847-1618665 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References