80089

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2581073..2581596 Replicon chromosome
Accession NZ_CP022906
Organism Staphylococcus aureus strain 546

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag CGP99_RS13690 Protein ID WP_000074048.1
Coordinates 2581073..2581339 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag CGP99_RS13695 Protein ID WP_000587616.1
Coordinates 2581339..2581596 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP99_RS13670 2576380..2577567 - 1188 WP_000026194.1 MFS transporter -
CGP99_RS13675 2577963..2578739 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
CGP99_RS13680 2578732..2579394 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
CGP99_RS13685 2579642..2580718 - 1077 WP_001076671.1 M42 family metallopeptidase -
CGP99_RS13690 2581073..2581339 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
CGP99_RS13695 2581339..2581596 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CGP99_RS13700 2581702..2581896 - 195 WP_001790145.1 hypothetical protein -
CGP99_RS13705 2581955..2582410 + 456 WP_000732082.1 DUF1307 domain-containing protein -
CGP99_RS13710 2582578..2584155 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
CGP99_RS13715 2584350..2585099 + 750 WP_000072443.1 hypothetical protein -
CGP99_RS13720 2585323..2586516 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T80089 WP_000074048.1 NZ_CP022906:c2581339-2581073 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T80089 NZ_CP022906:c2581339-2581073 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT80089 WP_000587616.1 NZ_CP022906:c2581596-2581339 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT80089 NZ_CP022906:c2581596-2581339 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References