Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2038422..2038845 Replicon chromosome
Accession NZ_CP022906
Organism Staphylococcus aureus strain 546

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag CGP99_RS10655 Protein ID WP_001065110.1
Coordinates 2038594..2038845 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag CGP99_RS10650 Protein ID WP_000028425.1
Coordinates 2038422..2038604 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP99_RS10610 2033815..2034105 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
CGP99_RS10615 2034239..2034343 + 105 WP_015978074.1 hypothetical protein -
CGP99_RS10620 2034446..2036893 - 2448 WP_115276637.1 virulence-associated E family protein -
CGP99_RS10625 2036946..2037146 - 201 WP_000265258.1 DUF1514 family protein -
CGP99_RS10630 2037214..2037366 - 153 WP_000595237.1 transcriptional activator RinB -
CGP99_RS10635 2037359..2037595 - 237 WP_000483477.1 hypothetical protein -
CGP99_RS10640 2037620..2037856 - 237 WP_000195806.1 DUF1381 domain-containing protein -
CGP99_RS10645 2037893..2038429 - 537 WP_000185703.1 dUTPase -
CGP99_RS10650 2038422..2038604 - 183 WP_000028425.1 hypothetical protein Antitoxin
CGP99_RS10655 2038594..2038845 - 252 WP_001065110.1 DUF1024 family protein Toxin
CGP99_RS10660 2038860..2039108 - 249 WP_000177805.1 phi PVL orf 51-like protein -
CGP99_RS10665 2039108..2039362 - 255 WP_000111495.1 DUF3310 domain-containing protein -
CGP99_RS10670 2039362..2039721 - 360 WP_000117792.1 hypothetical protein -
CGP99_RS10675 2039722..2039907 - 186 WP_001187264.1 DUF3113 family protein -
CGP99_RS10680 2039907..2040314 - 408 WP_000401950.1 RusA family crossover junction endodeoxyribonuclease -
CGP99_RS10685 2040324..2040545 - 222 WP_001123684.1 DUF3269 family protein -
CGP99_RS10690 2040558..2040716 - 159 WP_000628839.1 hypothetical protein -
CGP99_RS10695 2040713..2041498 - 786 WP_114647922.1 ATP-binding protein -
CGP99_RS10700 2041511..2042242 - 732 WP_000132048.1 helix-turn-helix domain-containing protein -
CGP99_RS10710 2042307..2042588 + 282 WP_000414755.1 hypothetical protein -
CGP99_RS15525 2042581..2042730 - 150 WP_001081076.1 hypothetical protein -
CGP99_RS10715 2042727..2043401 - 675 WP_031928974.1 phi PV83 orf 19-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2003926..2052394 48468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T80082 WP_001065110.1 NZ_CP022906:c2038845-2038594 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T80082 NZ_CP022906:c2038845-2038594 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT80082 WP_000028425.1 NZ_CP022906:c2038604-2038422 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT80082 NZ_CP022906:c2038604-2038422 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References