Detailed information of TA system TA080076

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1581962..1582541
• Replicon: chromosome
• Accession: NZ_CP022906
• Organism: Staphylococcus aureus strain 546

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CGP99_RS08080
• Protein ID: WP_001025401.1
• Coordinates: 1582296..1582541 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1581962..1582327 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP99_RS08040	1578705..1579262	-	558	WP_000645045.1	DUF2815 family protein	-
CGP99_RS08045	1579288..1580454	-	1167	WP_115276638.1	DUF2800 domain-containing protein	-
CGP99_RS08050	1580451..1580813	-	363	WP_031857745.1	hypothetical protein	-
CGP99_RS08055	1580828..1581151	-	324	WP_000174994.1	hypothetical protein	-
CGP99_RS08060	1581230..1581391	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
CGP99_RS08065	1581404..1581667	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CGP99_RS08070	1581692..1581907	-	216	WP_031867168.1	hypothetical protein	-
CGP99_RS08075	1581962..1582327	+	366	WP_001128433.1	hypothetical protein	Antitoxin
CGP99_RS08080	1582296..1582541	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CGP99_RS08085	1582591..1582809	-	219	WP_001001383.1	hypothetical protein	-
CGP99_RS08090	1582825..1583601	-	777	WP_001148559.1	phage antirepressor	-
CGP99_RS08095	1583627..1583854	-	228	WP_001030311.1	hypothetical protein	-
CGP99_RS08100	1584026..1584640	+	615	WP_000801423.1	XRE family transcriptional regulator	-
CGP99_RS08105	1584656..1585576	+	921	WP_000348133.1	3'-5' exoribonuclease	-
CGP99_RS08110	1585673..1585855	+	183	WP_000705240.1	hypothetical protein	-
CGP99_RS08115	1585892..1586038	+	147	WP_072433242.1	hypothetical protein	-
CGP99_RS08120	1586035..1586649	-	615	WP_000191463.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1541317..1600736	59419

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T80076 WP_001025401.1 NZ_CP022906:c1582541-1582296 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T80076 NZ_CP022906:c1582541-1582296 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT80076 NZ_CP022906:1581962-1582327 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin