Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1574931..1575354 Replicon chromosome
Accession NZ_CP022906
Organism Staphylococcus aureus strain 546

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag CGP99_RS08005 Protein ID WP_001065110.1
Coordinates 1575103..1575354 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag CGP99_RS08000 Protein ID WP_000028425.1
Coordinates 1574931..1575113 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP99_RS07960 1570324..1570614 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
CGP99_RS07965 1570748..1570852 + 105 WP_015978074.1 hypothetical protein -
CGP99_RS07970 1570955..1573402 - 2448 WP_115276637.1 virulence-associated E family protein -
CGP99_RS07975 1573455..1573655 - 201 WP_000265258.1 DUF1514 family protein -
CGP99_RS07980 1573723..1573875 - 153 WP_000595237.1 transcriptional activator RinB -
CGP99_RS07985 1573868..1574104 - 237 WP_000483477.1 hypothetical protein -
CGP99_RS07990 1574129..1574365 - 237 WP_000195806.1 DUF1381 domain-containing protein -
CGP99_RS07995 1574402..1574938 - 537 WP_000185703.1 dUTPase -
CGP99_RS08000 1574931..1575113 - 183 WP_000028425.1 hypothetical protein Antitoxin
CGP99_RS08005 1575103..1575354 - 252 WP_001065110.1 DUF1024 family protein Toxin
CGP99_RS08010 1575369..1575611 - 243 WP_000132193.1 hypothetical protein -
CGP99_RS08015 1575626..1575826 - 201 WP_000235324.1 hypothetical protein -
CGP99_RS08020 1575829..1576086 - 258 WP_000022728.1 DUF3310 domain-containing protein -
CGP99_RS08025 1576086..1576487 - 402 WP_031776133.1 phage DNA polymerase -
CGP99_RS08030 1576487..1576672 - 186 WP_001164629.1 DUF3113 family protein -
CGP99_RS08035 1576685..1578637 - 1953 WP_001802096.1 DNA polymerase -
CGP99_RS08040 1578705..1579262 - 558 WP_000645045.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1541317..1600736 59419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T80075 WP_001065110.1 NZ_CP022906:c1575354-1575103 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T80075 NZ_CP022906:c1575354-1575103 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT80075 WP_000028425.1 NZ_CP022906:c1575113-1574931 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT80075 NZ_CP022906:c1575113-1574931 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References