Detailed information of TA system TA080059

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1027435..1027773
• Replicon: chromosome
• Accession: NZ_CP022905
• Organism: Staphylococcus aureus strain 628

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CGQ03_RS05330
• Protein ID: WP_011447039.1
• Coordinates: 1027435..1027611 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1027599..1027773 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGQ03_RS05310	1022670..1026455	+	3786	WP_000582178.1	hypothetical protein	-
CGQ03_RS05315	1026445..1026597	+	153	WP_001153681.1	hypothetical protein	-
CGQ03_RS05320	1026644..1026931	+	288	WP_001040261.1	hypothetical protein	-
CGQ03_RS05325	1026989..1027285	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CGQ03_RS05330	1027435..1027611	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1027599..1027773	-	175	-	-	Antitoxin
CGQ03_RS05340	1027823..1028077	+	255	WP_000611512.1	phage holin	-
CGQ03_RS05345	1028089..1028844	+	756	WP_000861038.1	CHAP domain-containing protein	-
CGQ03_RS05350	1029035..1029526	+	492	WP_000919350.1	staphylokinase	-
CGQ03_RS05360	1030176..1030511	+	336	Protein_989	SH3 domain-containing protein	-
CGQ03_RS05365	1030606..1031055	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CGQ03_RS05370	1031739..1032089	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
CGQ03_RS05375	1032142..1032402	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	975752..1032089	56337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T80059 WP_011447039.1 NZ_CP022905:1027435-1027611 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T80059 NZ_CP022905:1027435-1027611 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT80059 NZ_CP022905:c1027773-1027599 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin