Detailed information of TA system TA080034

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1824839..1825146
• Replicon: chromosome
• Accession: NZ_CP022903
• Organism: Staphylococcus aureus strain 187

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CGQ01_RS09575
• Protein ID: WP_011447039.1
• Coordinates: 1824970..1825146 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1824839..1824978 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGQ01_RS09530	1820179..1820439	+	261	WP_001791826.1	hypothetical protein	-
CGQ01_RS09535	1820492..1820842	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CGQ01_RS09540	1821526..1821975	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CGQ01_RS09545	1822070..1822405	-	336	Protein_1751	SH3 domain-containing protein	-
CGQ01_RS09555	1823055..1823546	-	492	WP_000919350.1	staphylokinase	-
CGQ01_RS09560	1823737..1824492	-	756	WP_000861038.1	CHAP domain-containing protein	-
CGQ01_RS09565	1824504..1824758	-	255	WP_000611512.1	phage holin	-
CGQ01_RS09570	1824810..1824917	+	108	WP_001791821.1	hypothetical protein	-
-	1824839..1824978	+	140	NuclAT_0	-	Antitoxin
-	1824839..1824978	+	140	NuclAT_0	-	Antitoxin
-	1824839..1824978	+	140	NuclAT_0	-	Antitoxin
-	1824839..1824978	+	140	NuclAT_0	-	Antitoxin
CGQ01_RS09575	1824970..1825146	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CGQ01_RS09580	1825296..1825592	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CGQ01_RS09585	1825650..1825937	-	288	WP_001040261.1	hypothetical protein	-
CGQ01_RS09590	1825984..1826136	-	153	WP_001153681.1	hypothetical protein	-
CGQ01_RS09595	1826126..1829911	-	3786	WP_000582178.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / groEL / hld	1816996..1891734	74738

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T80034 WP_011447039.1 NZ_CP022903:c1825146-1824970 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T80034 NZ_CP022903:c1825146-1824970 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT80034 NZ_CP022903:1824839-1824978 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin