Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 298517..299034 Replicon chromosome
Accession NZ_CP022903
Organism Staphylococcus aureus strain 187

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag CGQ01_RS01460 Protein ID WP_000113265.1
Coordinates 298768..299034 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CGQ01_RS01455 Protein ID WP_000584499.1
Coordinates 298517..298768 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ01_RS01425 294215..294934 + 720 WP_000479576.1 amino acid ABC transporter permease -
CGQ01_RS01430 294931..295662 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CGQ01_RS01435 295759..297009 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
CGQ01_RS01440 297264..297626 + 363 WP_000819843.1 DUF4467 domain-containing protein -
CGQ01_RS01445 297645..298244 + 600 WP_000162810.1 DsbA family protein -
CGQ01_RS01450 298251..298352 + 102 Protein_262 hypothetical protein -
CGQ01_RS01455 298517..298768 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CGQ01_RS01460 298768..299034 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
CGQ01_RS01465 299069..299140 + 72 Protein_265 hypothetical protein -
CGQ01_RS01470 299329..300876 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CGQ01_RS01475 301062..301529 + 468 WP_000153347.1 SRPBCC domain-containing protein -
CGQ01_RS01480 301613..301795 + 183 WP_000230292.1 hypothetical protein -
CGQ01_RS01485 302012..302836 + 825 WP_000572038.1 formate/nitrite transporter family protein -
CGQ01_RS01490 303070..303606 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T80024 WP_000113265.1 NZ_CP022903:298768-299034 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T80024 NZ_CP022903:298768-299034 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT80024 WP_000584499.1 NZ_CP022903:298517-298768 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT80024 NZ_CP022903:298517-298768 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References