Detailed information of TA system TA080024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 298517..299034
• Replicon: chromosome
• Accession: NZ_CP022903
• Organism: Staphylococcus aureus strain 187

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: CGQ01_RS01460
• Protein ID: WP_000113265.1
• Coordinates: 298768..299034 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: CGQ01_RS01455
• Protein ID: WP_000584499.1
• Coordinates: 298517..298768 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGQ01_RS01425	294215..294934	+	720	WP_000479576.1	amino acid ABC transporter permease	-
CGQ01_RS01430	294931..295662	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
CGQ01_RS01435	295759..297009	-	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
CGQ01_RS01440	297264..297626	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
CGQ01_RS01445	297645..298244	+	600	WP_000162810.1	DsbA family protein	-
CGQ01_RS01450	298251..298352	+	102	Protein_262	hypothetical protein	-
CGQ01_RS01455	298517..298768	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CGQ01_RS01460	298768..299034	+	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
CGQ01_RS01465	299069..299140	+	72	Protein_265	hypothetical protein	-
CGQ01_RS01470	299329..300876	+	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
CGQ01_RS01475	301062..301529	+	468	WP_000153347.1	SRPBCC domain-containing protein	-
CGQ01_RS01480	301613..301795	+	183	WP_000230292.1	hypothetical protein	-
CGQ01_RS01485	302012..302836	+	825	WP_000572038.1	formate/nitrite transporter family protein	-
CGQ01_RS01490	303070..303606	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T80024 WP_000113265.1 NZ_CP022903:298768-299034 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T80024 NZ_CP022903:298768-299034 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT80024 WP_000584499.1 NZ_CP022903:298517-298768 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT80024 NZ_CP022903:298517-298768 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60