80006

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1574927..1575350 Replicon chromosome
Accession NZ_CP022902
Organism Staphylococcus aureus strain 165

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag CGP98_RS08005 Protein ID WP_001065110.1
Coordinates 1575099..1575350 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag CGP98_RS08000 Protein ID WP_000028425.1
Coordinates 1574927..1575109 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP98_RS07960 1570320..1570610 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
CGP98_RS07965 1570744..1570848 + 105 WP_015978074.1 hypothetical protein -
CGP98_RS07970 1570951..1573398 - 2448 WP_115276637.1 virulence-associated E family protein -
CGP98_RS07975 1573451..1573651 - 201 WP_000265258.1 DUF1514 family protein -
CGP98_RS07980 1573719..1573871 - 153 WP_000595237.1 transcriptional activator RinB -
CGP98_RS07985 1573864..1574100 - 237 WP_000483477.1 hypothetical protein -
CGP98_RS07990 1574125..1574361 - 237 WP_000195806.1 DUF1381 domain-containing protein -
CGP98_RS07995 1574398..1574934 - 537 WP_000185703.1 dUTPase -
CGP98_RS08000 1574927..1575109 - 183 WP_000028425.1 hypothetical protein Antitoxin
CGP98_RS08005 1575099..1575350 - 252 WP_001065110.1 DUF1024 family protein Toxin
CGP98_RS08010 1575365..1575607 - 243 WP_000132193.1 hypothetical protein -
CGP98_RS08015 1575622..1575822 - 201 WP_000235324.1 hypothetical protein -
CGP98_RS08020 1575825..1576082 - 258 WP_000022728.1 DUF3310 domain-containing protein -
CGP98_RS08025 1576082..1576483 - 402 WP_031776133.1 phage DNA polymerase -
CGP98_RS08030 1576483..1576668 - 186 WP_001164629.1 DUF3113 family protein -
CGP98_RS08035 1576681..1578633 - 1953 WP_001802096.1 DNA polymerase -
CGP98_RS08040 1578701..1579258 - 558 WP_000645045.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1541313..1600732 59419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T80006 WP_001065110.1 NZ_CP022902:c1575350-1575099 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T80006 NZ_CP022902:c1575350-1575099 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT80006 WP_000028425.1 NZ_CP022902:c1575109-1574927 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT80006 NZ_CP022902:c1575109-1574927 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References