Detailed information of TA system TA079978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1965964..1966263
• Replicon: chromosome
• Accession: NZ_CP022900
• Organism: Staphylococcus aureus strain 468

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CGP96_RS09880
• Protein ID: WP_011447039.1
• Coordinates: 1966087..1966263 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1965964..1966019 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP96_RS09835	1961522..1962037	-	516	WP_000163281.1	type 1 glutamine amidotransferase	-
CGP96_RS09840	1962167..1962328	-	162	WP_001005407.1	hypothetical protein	-
CGP96_RS09845	1962675..1962755	+	81	WP_100250272.1	hypothetical protein	-
CGP96_RS09850	1962825..1963562	-	738	WP_000278830.1	hypothetical protein	-
CGP96_RS09855	1963569..1964363	-	795	WP_000238963.1	phosphatidylinositol kinase	-
CGP96_RS09865	1964854..1965609	-	756	WP_000861038.1	CHAP domain-containing protein	-
CGP96_RS09870	1965621..1965875	-	255	WP_000611512.1	phage holin	-
CGP96_RS09875	1965927..1966034	+	108	WP_001791821.1	hypothetical protein	-
-	1965956..1966095	+	140	NuclAT_0	-	-
-	1965956..1966095	+	140	NuclAT_0	-	-
-	1965956..1966095	+	140	NuclAT_0	-	-
-	1965956..1966095	+	140	NuclAT_0	-	-
-	1965964..1966019	+	56	-	-	Antitoxin
CGP96_RS09880	1966087..1966263	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CGP96_RS09885	1966413..1966709	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CGP96_RS09890	1966767..1967054	-	288	WP_001040261.1	hypothetical protein	-
CGP96_RS09895	1967101..1967253	-	153	WP_001153681.1	hypothetical protein	-
CGP96_RS09900	1967243..1971028	-	3786	WP_115283867.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1961522..2002872	41350

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T79978 WP_011447039.1 NZ_CP022900:c1966263-1966087 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79978 NZ_CP022900:c1966263-1966087 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT79978 NZ_CP022900:1965964-1966019 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin