Detailed information of TA system TA079974

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1876964..1877144
• Replicon: chromosome
• Accession: NZ_CP022900
• Organism: Staphylococcus aureus strain 468

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: CGP96_RS09240
• Protein ID: WP_001801861.1
• Coordinates: 1876964..1877059 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1877087..1877144 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP96_RS09205	1872108..1872734	+	627	WP_000669038.1	hypothetical protein	-
CGP96_RS09210	1872775..1873119	+	345	WP_000627550.1	DUF3969 family protein	-
CGP96_RS09215	1873217..1873789	+	573	WP_000414222.1	hypothetical protein	-
CGP96_RS09220	1873938..1875305	-	1368	WP_001093574.1	FRG domain-containing protein	-
CGP96_RS09225	1875305..1875874	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
CGP96_RS09230	1876067..1876513	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
CGP96_RS09240	1876964..1877059	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1877087..1877144	-	58	-	-	Antitoxin
CGP96_RS09245	1877182..1877283	+	102	WP_001791232.1	hypothetical protein	-
CGP96_RS09250	1877458..1877901	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
CGP96_RS09255	1877901..1878344	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
CGP96_RS09260	1878344..1878786	-	443	Protein_1749	DUF1433 domain-containing protein	-
CGP96_RS09265	1879311..1881731	+	2421	WP_000182553.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T79974 WP_001801861.1 NZ_CP022900:1876964-1877059 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T79974 NZ_CP022900:1876964-1877059 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT79974 NZ_CP022900:c1877144-1877087 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin