Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2483529..2484046 Replicon chromosome
Accession NZ_CP022899
Organism Staphylococcus aureus strain 143

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag CGP95_RS12765 Protein ID WP_000251928.1
Coordinates 2483529..2483795 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag CGP95_RS12770 Protein ID WP_000584497.1
Coordinates 2483795..2484046 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP95_RS12740 2478737..2479273 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
CGP95_RS12745 2479741..2480565 - 825 WP_000594640.1 formate/nitrite transporter family protein -
CGP95_RS12750 2480768..2480950 - 183 WP_000079140.1 hypothetical protein -
CGP95_RS12755 2481036..2481503 - 468 WP_000153340.1 SRPBCC domain-containing protein -
CGP95_RS12760 2481689..2483236 - 1548 WP_115283888.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CGP95_RS12765 2483529..2483795 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
CGP95_RS12770 2483795..2484046 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CGP95_RS12775 2484210..2484310 - 101 Protein_2373 hypothetical protein -
CGP95_RS12780 2484317..2484916 - 600 WP_000162804.1 DsbA family protein -
CGP95_RS12785 2484935..2485297 - 363 WP_000819843.1 DUF4467 domain-containing protein -
CGP95_RS12790 2485552..2486802 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
CGP95_RS12795 2486899..2487630 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
CGP95_RS12800 2487627..2488346 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T79969 WP_000251928.1 NZ_CP022899:c2483795-2483529 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T79969 NZ_CP022899:c2483795-2483529 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT79969 WP_000584497.1 NZ_CP022899:c2484046-2483795 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT79969 NZ_CP022899:c2484046-2483795 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References