Detailed information of TA system TA079961

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1965931..1966238
• Replicon: chromosome
• Accession: NZ_CP022899
• Organism: Staphylococcus aureus strain 143

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CGP95_RS09880
• Protein ID: WP_011447039.1
• Coordinates: 1966062..1966238 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1965931..1966070 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP95_RS09835	1961497..1962012	-	516	WP_000163281.1	type 1 glutamine amidotransferase	-
CGP95_RS09840	1962142..1962303	-	162	WP_001005407.1	hypothetical protein	-
CGP95_RS09845	1962650..1962730	+	81	WP_100250272.1	hypothetical protein	-
CGP95_RS09850	1962800..1963537	-	738	WP_000278830.1	hypothetical protein	-
CGP95_RS09855	1963544..1964338	-	795	WP_000238963.1	phosphatidylinositol kinase	-
CGP95_RS09865	1964829..1965584	-	756	WP_000861038.1	CHAP domain-containing protein	-
CGP95_RS09870	1965596..1965850	-	255	WP_000611512.1	phage holin	-
CGP95_RS09875	1965902..1966009	+	108	WP_001791821.1	hypothetical protein	-
-	1965931..1966070	+	140	NuclAT_0	-	Antitoxin
-	1965931..1966070	+	140	NuclAT_0	-	Antitoxin
-	1965931..1966070	+	140	NuclAT_0	-	Antitoxin
-	1965931..1966070	+	140	NuclAT_0	-	Antitoxin
CGP95_RS09880	1966062..1966238	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CGP95_RS09885	1966388..1966684	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CGP95_RS09890	1966742..1967029	-	288	WP_001040261.1	hypothetical protein	-
CGP95_RS09895	1967076..1967228	-	153	WP_001153681.1	hypothetical protein	-
CGP95_RS09900	1967218..1971003	-	3786	WP_115283867.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1961497..2000867	39370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T79961 WP_011447039.1 NZ_CP022899:c1966238-1966062 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79961 NZ_CP022899:c1966238-1966062 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT79961 NZ_CP022899:1965931-1966070 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin