Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2528061..2528584 Replicon chromosome
Accession NZ_CP022898
Organism Staphylococcus aureus strain 422

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag CGP94_RS13165 Protein ID WP_000074048.1
Coordinates 2528061..2528327 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag CGP94_RS13170 Protein ID WP_000587617.1
Coordinates 2528327..2528584 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP94_RS13145 2523271..2524458 - 1188 WP_000026189.1 MFS transporter -
CGP94_RS13150 2524853..2525629 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
CGP94_RS13155 2525622..2526284 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
CGP94_RS13160 2526629..2527705 - 1077 WP_115385588.1 M42 family metallopeptidase -
CGP94_RS13165 2528061..2528327 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
CGP94_RS13170 2528327..2528584 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CGP94_RS13180 2528944..2529399 + 456 WP_000732082.1 DUF1307 domain-containing protein -
CGP94_RS13185 2529567..2531144 - 1578 WP_000971447.1 FMN-binding glutamate synthase family protein -
CGP94_RS13190 2531339..2532088 + 750 WP_000072454.1 CPBP family intramembrane metalloprotease -
CGP94_RS13195 2532312..2533505 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T79955 WP_000074048.1 NZ_CP022898:c2528327-2528061 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T79955 NZ_CP022898:c2528327-2528061 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT79955 WP_000587617.1 NZ_CP022898:c2528584-2528327 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT79955 NZ_CP022898:c2528584-2528327 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References