Detailed information of TA system TA079945

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2037856..2038163
• Replicon: chromosome
• Accession: NZ_CP022898
• Organism: Staphylococcus aureus strain 422

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: CGP94_RS10445
• Protein ID: WP_115385564.1
• Coordinates: 2037987..2038163 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2037856..2037995 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP94_RS10385	2033423..2033602	+	180	WP_000669791.1	hypothetical protein	-
CGP94_RS10395	2033913..2034173	+	261	WP_001791826.1	hypothetical protein	-
CGP94_RS10400	2034225..2034575	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CGP94_RS10405	2035086..2035421	-	336	Protein_1915	SH3 domain-containing protein	-
CGP94_RS10425	2036072..2036563	-	492	WP_000920038.1	staphylokinase	-
CGP94_RS10430	2036754..2037509	-	756	WP_107375239.1	CHAP domain-containing protein	-
CGP94_RS10435	2037521..2037775	-	255	WP_000611512.1	phage holin	-
CGP94_RS10440	2037827..2037934	+	108	WP_031762631.1	hypothetical protein	-
-	2037856..2037995	+	140	NuclAT_0	-	Antitoxin
-	2037856..2037995	+	140	NuclAT_0	-	Antitoxin
-	2037856..2037995	+	140	NuclAT_0	-	Antitoxin
-	2037856..2037995	+	140	NuclAT_0	-	Antitoxin
CGP94_RS10445	2037987..2038163	-	177	WP_115385564.1	putative holin-like toxin	Toxin
CGP94_RS10450	2038313..2038609	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CGP94_RS10455	2038667..2038954	-	288	WP_061839455.1	hypothetical protein	-
CGP94_RS10460	2039001..2039153	-	153	WP_001153681.1	hypothetical protein	-
CGP94_RS10465	2039143..2042928	-	3786	WP_115385565.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2034225..2089215	54990

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6821.39 Da
• Isoelectric Point: 10.6777

>T79945 WP_115385564.1 NZ_CP022898:c2038163-2037987 [Staphylococcus aureus]
MDRWWLSEYKEVAPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79945 NZ_CP022898:c2038163-2037987 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGCGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT79945 NZ_CP022898:2037856-2037995 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin