Detailed information of TA system TA079932

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2037857..2038164
• Replicon: chromosome
• Accession: NZ_CP022897
• Organism: Staphylococcus aureus strain 128

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: CGP93_RS10445
• Protein ID: WP_115385564.1
• Coordinates: 2037988..2038164 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2037857..2037996 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP93_RS10385	2033424..2033603	+	180	WP_000669791.1	hypothetical protein	-
CGP93_RS10395	2033914..2034174	+	261	WP_001791826.1	hypothetical protein	-
CGP93_RS10400	2034226..2034576	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CGP93_RS10405	2035087..2035422	-	336	Protein_1911	SH3 domain-containing protein	-
CGP93_RS10425	2036073..2036564	-	492	WP_000920038.1	staphylokinase	-
CGP93_RS10430	2036755..2037510	-	756	WP_107375239.1	CHAP domain-containing protein	-
CGP93_RS10435	2037522..2037776	-	255	WP_000611512.1	phage holin	-
CGP93_RS10440	2037828..2037935	+	108	WP_031762631.1	hypothetical protein	-
-	2037857..2037996	+	140	NuclAT_0	-	Antitoxin
-	2037857..2037996	+	140	NuclAT_0	-	Antitoxin
-	2037857..2037996	+	140	NuclAT_0	-	Antitoxin
-	2037857..2037996	+	140	NuclAT_0	-	Antitoxin
CGP93_RS10445	2037988..2038164	-	177	WP_115385564.1	putative holin-like toxin	Toxin
CGP93_RS10450	2038314..2038610	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CGP93_RS10455	2038668..2038955	-	288	WP_061839455.1	hypothetical protein	-
CGP93_RS10460	2039002..2039154	-	153	WP_001153681.1	hypothetical protein	-
CGP93_RS10465	2039144..2042929	-	3786	WP_115385565.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2034226..2089216	54990

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6821.39 Da
• Isoelectric Point: 10.6777

>T79932 WP_115385564.1 NZ_CP022897:c2038164-2037988 [Staphylococcus aureus]
MDRWWLSEYKEVAPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79932 NZ_CP022897:c2038164-2037988 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGCGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT79932 NZ_CP022897:2037857-2037996 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin