Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2495444..2495628 Replicon chromosome
Accession NZ_CP022896
Organism Staphylococcus aureus strain 277

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag CGP92_RS12870 Protein ID WP_000482647.1
Coordinates 2495521..2495628 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2495444..2495504 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP92_RS12845 2490954..2491121 - 168 Protein_2382 hypothetical protein -
CGP92_RS12855 2491352..2493085 - 1734 WP_000486505.1 ABC transporter ATP-binding protein/permease -
CGP92_RS12860 2493110..2494873 - 1764 WP_001064829.1 ABC transporter ATP-binding protein/permease -
- 2495444..2495504 + 61 - - Antitoxin
CGP92_RS12870 2495521..2495628 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
CGP92_RS12875 2495762..2496148 - 387 WP_000779351.1 flippase GtxA -
CGP92_RS12880 2496416..2497558 + 1143 WP_001176855.1 glycerate kinase -
CGP92_RS12885 2497618..2498277 + 660 WP_000831298.1 membrane protein -
CGP92_RS12890 2498459..2499670 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
CGP92_RS12895 2499793..2500266 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T79928 WP_000482647.1 NZ_CP022896:c2495628-2495521 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T79928 NZ_CP022896:c2495628-2495521 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT79928 NZ_CP022896:2495444-2495504 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References