Detailed information of TA system TA079922

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2053198..2053621
• Replicon: chromosome
• Accession: NZ_CP022896
• Organism: Staphylococcus aureus strain 277

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5S9I4Y6
• Locus tag: CGP92_RS10415
• Protein ID: WP_001065091.1
• Coordinates: 2053370..2053621 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A0E0VQM8
• Locus tag: CGP92_RS10410
• Protein ID: WP_000028422.1
• Coordinates: 2053198..2053380 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP92_RS10365	2048584..2050245	-	1662	WP_000625088.1	terminase large subunit	-
CGP92_RS10370	2050242..2050586	-	345	WP_000402904.1	hypothetical protein	-
CGP92_RS10375	2050716..2051015	-	300	WP_000988336.1	HNH endonuclease	-
CGP92_RS10380	2051247..2051663	-	417	WP_000590122.1	hypothetical protein	-
CGP92_RS10385	2051691..2051891	-	201	WP_000265043.1	DUF1514 family protein	-
CGP92_RS10390	2051891..2052040	-	150	WP_000595265.1	transcriptional activator RinB	-
CGP92_RS10395	2052037..2052423	-	387	WP_000592207.1	hypothetical protein	-
CGP92_RS10400	2052420..2052626	-	207	WP_000195803.1	DUF1381 domain-containing protein	-
CGP92_RS10405	2052663..2053205	-	543	WP_000185659.1	dUTP pyrophosphatase	-
CGP92_RS10410	2053198..2053380	-	183	WP_000028422.1	hypothetical protein	Antitoxin
CGP92_RS10415	2053370..2053621	-	252	WP_001065091.1	DUF1024 family protein	Toxin
CGP92_RS14455	2053614..2053781	-	168	WP_001624242.1	hypothetical protein	-
CGP92_RS10420	2053793..2054035	-	243	WP_000131366.1	hypothetical protein	-
CGP92_RS10425	2054039..2054407	-	369	WP_000101274.1	hypothetical protein	-
CGP92_RS10430	2054420..2054729	-	310	Protein_1936	RusA family crossover junction endodeoxyribonuclease	-
CGP92_RS10435	2054738..2054956	-	219	WP_000338531.1	hypothetical protein	-
CGP92_RS10440	2054963..2055847	-	885	WP_000148316.1	DnaD domain protein	-
CGP92_RS10445	2055877..2056347	-	471	WP_000934764.1	single-stranded DNA-binding protein	-
CGP92_RS10450	2056348..2056965	-	618	WP_071621397.1	MBL fold metallo-hydrolase	-
CGP92_RS10455	2057046..2057966	-	921	WP_000138472.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL	2019756..2078761	59005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9349.22 Da
• Isoelectric Point: 3.9473

>T79922 WP_001065091.1 NZ_CP022896:c2053621-2053370 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Nucleotide

• Length: 252 bp

>T79922 NZ_CP022896:c2053621-2053370 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6741.63 Da
• Isoelectric Point: 4.2658

>AT79922 WP_000028422.1 NZ_CP022896:c2053380-2053198 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Nucleotide

• Length: 183 bp

>AT79922 NZ_CP022896:c2053380-2053198 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Structures

Toxin

• AlphaFold DB: A0A5S9I4Y6

Antitoxin

• AlphaFold DB: A0A0E0VQM8