Detailed information of TA system TA079919

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2029879..2030186
• Replicon: chromosome
• Accession: NZ_CP022896
• Organism: Staphylococcus aureus strain 277

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CGP92_RS10265
• Protein ID: WP_011447039.1
• Coordinates: 2030010..2030186 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2029879..2030018 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP92_RS10220	2025217..2025477	+	261	WP_001791826.1	hypothetical protein	-
CGP92_RS10225	2025530..2025880	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CGP92_RS10230	2026566..2027015	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CGP92_RS10235	2027110..2027445	-	336	Protein_1897	SH3 domain-containing protein	-
CGP92_RS10245	2028095..2028586	-	492	WP_000919350.1	staphylokinase	-
CGP92_RS10250	2028777..2029532	-	756	WP_000861038.1	CHAP domain-containing protein	-
CGP92_RS10255	2029544..2029798	-	255	WP_000611512.1	phage holin	-
CGP92_RS10260	2029850..2029957	+	108	WP_001791821.1	hypothetical protein	-
-	2029879..2030018	+	140	NuclAT_0	-	Antitoxin
-	2029879..2030018	+	140	NuclAT_0	-	Antitoxin
-	2029879..2030018	+	140	NuclAT_0	-	Antitoxin
-	2029879..2030018	+	140	NuclAT_0	-	Antitoxin
CGP92_RS10265	2030010..2030186	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CGP92_RS10270	2030295..2031068	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
CGP92_RS10280	2031489..2031863	-	375	WP_000340977.1	hypothetical protein	-
CGP92_RS10285	2031919..2032206	-	288	WP_001040259.1	hypothetical protein	-
CGP92_RS10290	2032253..2032405	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL	2019756..2078761	59005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T79919 WP_011447039.1 NZ_CP022896:c2030186-2030010 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79919 NZ_CP022896:c2030186-2030010 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT79919 NZ_CP022896:2029879-2030018 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin