Detailed information of TA system TA079906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2054205..2054628
• Replicon: chromosome
• Accession: NZ_CP022895
• Organism: Staphylococcus aureus strain 85

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5S9I4Y6
• Locus tag: CGP91_RS10420
• Protein ID: WP_001065091.1
• Coordinates: 2054377..2054628 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A0E0VQM8
• Locus tag: CGP91_RS10415
• Protein ID: WP_000028422.1
• Coordinates: 2054205..2054387 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP91_RS10370	2049591..2051252	-	1662	WP_000625088.1	terminase large subunit	-
CGP91_RS10375	2051249..2051593	-	345	WP_000402904.1	hypothetical protein	-
CGP91_RS10380	2051723..2052022	-	300	WP_000988336.1	HNH endonuclease	-
CGP91_RS10385	2052254..2052670	-	417	WP_000590122.1	hypothetical protein	-
CGP91_RS10390	2052698..2052898	-	201	WP_000265043.1	DUF1514 family protein	-
CGP91_RS10395	2052898..2053047	-	150	WP_000595265.1	transcriptional activator RinB	-
CGP91_RS10400	2053044..2053430	-	387	WP_000592207.1	hypothetical protein	-
CGP91_RS10405	2053427..2053633	-	207	WP_000195803.1	DUF1381 domain-containing protein	-
CGP91_RS10410	2053670..2054212	-	543	WP_000185659.1	dUTP pyrophosphatase	-
CGP91_RS10415	2054205..2054387	-	183	WP_000028422.1	hypothetical protein	Antitoxin
CGP91_RS10420	2054377..2054628	-	252	WP_001065091.1	DUF1024 family protein	Toxin
CGP91_RS14460	2054621..2054788	-	168	WP_001624242.1	hypothetical protein	-
CGP91_RS10425	2054800..2055042	-	243	WP_000131366.1	hypothetical protein	-
CGP91_RS10430	2055046..2055414	-	369	WP_000101274.1	hypothetical protein	-
CGP91_RS10435	2055427..2055736	-	310	Protein_1937	RusA family crossover junction endodeoxyribonuclease	-
CGP91_RS10440	2055745..2055963	-	219	WP_000338531.1	hypothetical protein	-
CGP91_RS10445	2055970..2056854	-	885	WP_000148316.1	DnaD domain protein	-
CGP91_RS10450	2056884..2057354	-	471	WP_000934764.1	single-stranded DNA-binding protein	-
CGP91_RS10455	2057355..2057972	-	618	WP_071621397.1	MBL fold metallo-hydrolase	-
CGP91_RS10460	2058053..2058973	-	921	WP_000138472.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL	2020763..2079768	59005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9349.22 Da
• Isoelectric Point: 3.9473

>T79906 WP_001065091.1 NZ_CP022895:c2054628-2054377 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Nucleotide

• Length: 252 bp

>T79906 NZ_CP022895:c2054628-2054377 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6741.63 Da
• Isoelectric Point: 4.2658

>AT79906 WP_000028422.1 NZ_CP022895:c2054387-2054205 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Nucleotide

• Length: 183 bp

>AT79906 NZ_CP022895:c2054387-2054205 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Structures

Toxin

• AlphaFold DB: A0A5S9I4Y6

Antitoxin

• AlphaFold DB: A0A0E0VQM8