Detailed information of TA system TA079904

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2030894..2031193
• Replicon: chromosome
• Accession: NZ_CP022895
• Organism: Staphylococcus aureus strain 85

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CGP91_RS10270
• Protein ID: WP_011447039.1
• Coordinates: 2031017..2031193 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2030894..2030949 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP91_RS10225	2026224..2026484	+	261	WP_001791826.1	hypothetical protein	-
CGP91_RS10230	2026537..2026887	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CGP91_RS10235	2027573..2028022	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CGP91_RS10240	2028117..2028452	-	336	Protein_1898	SH3 domain-containing protein	-
CGP91_RS10250	2029102..2029593	-	492	WP_000919350.1	staphylokinase	-
CGP91_RS10255	2029784..2030539	-	756	WP_000861038.1	CHAP domain-containing protein	-
CGP91_RS10260	2030551..2030805	-	255	WP_000611512.1	phage holin	-
CGP91_RS10265	2030857..2030964	+	108	WP_001791821.1	hypothetical protein	-
-	2030886..2031025	+	140	NuclAT_0	-	-
-	2030886..2031025	+	140	NuclAT_0	-	-
-	2030886..2031025	+	140	NuclAT_0	-	-
-	2030886..2031025	+	140	NuclAT_0	-	-
-	2030894..2030949	+	56	-	-	Antitoxin
CGP91_RS10270	2031017..2031193	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CGP91_RS10275	2031302..2032075	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
CGP91_RS10285	2032496..2032870	-	375	WP_000340977.1	hypothetical protein	-
CGP91_RS10290	2032926..2033213	-	288	WP_001040259.1	hypothetical protein	-
CGP91_RS10295	2033260..2033412	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL	2020763..2079768	59005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T79904 WP_011447039.1 NZ_CP022895:c2031193-2031017 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79904 NZ_CP022895:c2031193-2031017 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT79904 NZ_CP022895:2030894-2030949 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin