Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2577568..2577752 Replicon chromosome
Accession NZ_CP022894
Organism Staphylococcus aureus strain 191

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag CGP90_RS13595 Protein ID WP_000482652.1
Coordinates 2577645..2577752 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2577568..2577628 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP90_RS13570 2573023..2573190 - 168 Protein_2505 hypothetical protein -
CGP90_RS13580 2573421..2575154 - 1734 WP_000486483.1 ABC transporter ATP-binding protein/permease -
CGP90_RS13585 2575179..2576942 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2577568..2577628 + 61 - - Antitoxin
CGP90_RS13595 2577645..2577752 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
CGP90_RS13600 2577886..2578272 - 387 WP_000779360.1 flippase GtxA -
CGP90_RS13605 2578540..2579682 + 1143 WP_001176863.1 glycerate kinase -
CGP90_RS13610 2579742..2580401 + 660 WP_000831302.1 hypothetical protein -
CGP90_RS13615 2580583..2581794 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
CGP90_RS13620 2581917..2582390 - 474 WP_015445934.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T79895 WP_000482652.1 NZ_CP022894:c2577752-2577645 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T79895 NZ_CP022894:c2577752-2577645 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT79895 NZ_CP022894:2577568-2577628 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References