Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2292441..2292657 Replicon chromosome
Accession NZ_CP022894
Organism Staphylococcus aureus strain 191

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag CGP90_RS12030 Protein ID WP_001802298.1
Coordinates 2292553..2292657 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2292441..2292496 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP90_RS12010 2288647..2289312 - 666 WP_001024095.1 SDR family oxidoreductase -
CGP90_RS12015 2289464..2289784 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
CGP90_RS12020 2289786..2290763 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
CGP90_RS12025 2291029..2292120 + 1092 WP_000495669.1 hypothetical protein -
- 2292441..2292496 + 56 - - Antitoxin
CGP90_RS12030 2292553..2292657 - 105 WP_001802298.1 hypothetical protein Toxin
CGP90_RS15340 2293174..2293344 + 171 WP_001792292.1 transposase -
CGP90_RS12040 2293337..2293495 + 159 WP_001792784.1 hypothetical protein -
CGP90_RS12050 2294153..2295010 - 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
CGP90_RS12055 2295078..2295860 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T79892 WP_001802298.1 NZ_CP022894:c2292657-2292553 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T79892 NZ_CP022894:c2292657-2292553 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT79892 NZ_CP022894:2292441-2292496 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References