Detailed information of TA system TA079868

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1027462..1027800
• Replicon: chromosome
• Accession: NZ_CP022893
• Organism: Staphylococcus aureus strain 61

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CGP89_RS05330
• Protein ID: WP_011447039.1
• Coordinates: 1027462..1027638 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1027626..1027800 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP89_RS05310	1022697..1026482	+	3786	WP_000582178.1	hypothetical protein	-
CGP89_RS05315	1026472..1026624	+	153	WP_001153681.1	hypothetical protein	-
CGP89_RS05320	1026671..1026958	+	288	WP_001040261.1	hypothetical protein	-
CGP89_RS05325	1027016..1027312	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CGP89_RS05330	1027462..1027638	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1027626..1027800	-	175	-	-	Antitoxin
CGP89_RS05340	1027850..1028104	+	255	WP_000611512.1	phage holin	-
CGP89_RS05345	1028116..1028871	+	756	WP_000861038.1	CHAP domain-containing protein	-
CGP89_RS05350	1029062..1029553	+	492	WP_000919350.1	staphylokinase	-
CGP89_RS05360	1030203..1030538	+	336	Protein_990	SH3 domain-containing protein	-
CGP89_RS05365	1030633..1031082	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CGP89_RS05370	1031766..1032116	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
CGP89_RS05375	1032169..1032429	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	975779..1032116	56337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T79868 WP_011447039.1 NZ_CP022893:1027462-1027638 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79868 NZ_CP022893:1027462-1027638 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT79868 NZ_CP022893:c1027800-1027626 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin