Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2449462..2449646 Replicon chromosome
Accession NZ_CP022892
Organism Staphylococcus aureus strain 54

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag CGP87_RS12795 Protein ID WP_000482650.1
Coordinates 2449539..2449646 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2449462..2449522 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP87_RS12770 2444992..2445159 - 168 WP_001790576.1 hypothetical protein -
CGP87_RS12780 2445390..2447123 - 1734 WP_115312408.1 ABC transporter ATP-binding protein/permease -
CGP87_RS12785 2447148..2448911 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2449462..2449522 + 61 - - Antitoxin
CGP87_RS12795 2449539..2449646 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
CGP87_RS12800 2449780..2450166 - 387 WP_000779358.1 flippase GtxA -
CGP87_RS12805 2450434..2451576 + 1143 WP_001176863.1 glycerate kinase -
CGP87_RS12810 2451636..2452295 + 660 WP_000831298.1 membrane protein -
CGP87_RS12815 2452477..2453688 + 1212 WP_001192076.1 multidrug effflux MFS transporter -
CGP87_RS12820 2453811..2454284 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T79863 WP_000482650.1 NZ_CP022892:c2449646-2449539 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T79863 NZ_CP022892:c2449646-2449539 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT79863 NZ_CP022892:2449462-2449522 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References