Detailed information of TA system TA079826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 55036..55555
• Replicon: chromosome
• Accession: NZ_CP022881
• Organism: Staphylococcus sp. M0911

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: ssp1_RS00240
• Protein ID: WP_075777702.1
• Coordinates: 55283..55555 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: ssp1_RS00235
• Protein ID: WP_075777703.1
• Coordinates: 55036..55290 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ssp1_RS00215	50073..51122	+	1050	WP_075777707.1	PTS transporter subunit IIC	-
ssp1_RS00220	51326..51577	+	252	WP_075777706.1	hypothetical protein	-
ssp1_RS00225	52025..52462	+	438	WP_075777705.1	hypothetical protein	-
ssp1_RS00230	52589..54790	-	2202	WP_075777704.1	YSIRK-type signal peptide-containing protein	-
ssp1_RS00235	55036..55290	+	255	WP_075777703.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ssp1_RS00240	55283..55555	+	273	WP_075777702.1	Txe/YoeB family addiction module toxin	Toxin
ssp1_RS00245	55838..57208	+	1371	WP_002450206.1	citrate:proton symporter	-
ssp1_RS00250	57301..57876	-	576	WP_107536102.1	NAD(P)H-dependent oxidoreductase	-
ssp1_RS00255	58220..59650	+	1431	WP_075777701.1	multidrug efflux MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10815.55 Da
• Isoelectric Point: 10.0373

>T79826 WP_075777702.1 NZ_CP022881:55283-55555 [Staphylococcus sp. M0911]
MSRLNILFTPDAFEDYKYWQIHDKKLLKKINHLIKGINRNGPLEGEGKPEALKGNFKGYYSRRINFEHRLVYKVHDSEII
IVSCKYHYFK

Nucleotide

• Length: 273 bp

>T79826 NZ_CP022881:55283-55555 [Staphylococcus sp. M0911]
ATGAGTAGATTAAATATTTTATTTACACCTGATGCATTTGAAGATTATAAATATTGGCAAATTCATGATAAAAAATTATT
AAAAAAGATTAACCATTTAATTAAAGGTATAAATCGTAATGGCCCACTCGAAGGTGAAGGAAAACCTGAAGCTTTGAAAG
GTAATTTTAAAGGATATTATAGTAGAAGAATCAATTTTGAACATAGGTTAGTTTATAAAGTACATGATTCAGAAATAATT
ATTGTTTCTTGTAAATATCATTATTTTAAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9344.33 Da
• Isoelectric Point: 4.2257

>AT79826 WP_075777703.1 NZ_CP022881:55036-55290 [Staphylococcus sp. M0911]
MAIVSYSIARKNFRSLIDKVNNDSDAVTITTNDSNAVLISESDYNAMMETLYLQQSPANAQHLAKSIEDAERGNTIKVDL
ESYE

Nucleotide

• Length: 255 bp

>AT79826 NZ_CP022881:55036-55290 [Staphylococcus sp. M0911]
ATGGCAATAGTATCGTACTCAATAGCTAGAAAAAATTTTAGAAGTTTAATAGATAAAGTTAACAATGATTCAGATGCGGT
GACTATAACAACTAATGATAGCAATGCTGTATTGATTTCTGAGTCAGATTACAATGCGATGATGGAGACATTATACCTCC
AACAATCCCCTGCCAATGCCCAACACTTGGCTAAATCTATAGAAGATGCTGAGCGTGGAAATACAATAAAGGTAGATTTA
GAATCATATGAGTAG